Hopkins, Georgina, Gomez, Nancy, Tucis, Davis, Bartlett, Laura, Steers, Graham, Burns, Ellie, Brown, Michaela, Harvey-Cowlishaw, Tyler, Santos, Rute, Lauder, Sarah N, Scurr, Martin ORCID: https://orcid.org/0000-0002-4120-0688, Capitani, Lorenzo, Burnell, Stephanie, Rees, Tara, Smart, Kathryn, Somerville, Michelle, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004, Perera, Marianne, Potts, Martin, Metaxaki, Marina, Krishna, Benjamin, Jackson, Hannah, Tighe, Paddy, Onion, David, Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567, Wills, Mark and Fairclough, Lucy 2024. Lower humoral and cellular immunity following asymptomatic SARS-CoV-2 infection compared to symptomatic infection in education (the ACE cohort). Journal of Clinical Immunology 44 (6) , 147. 10.1007/s10875-024-01739-0 |
Hulin-Curtis, Sarah, Geary, James, MacLachlan, Bruce, Altmann, Danny, Baillon, Laury, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Greenshields-Watson, Alex, Hesketh, Sophie, Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337, Jones, Ian, Lauder, Sarah, Mason, Georgina, Smart, Kathryn, Scourfield, Oliver, Scott, Jake, Sukhova, Ksenia, Stanton, Richard ORCID: https://orcid.org/0000-0002-6799-1182, Wall, Aaron, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Barclay, Wendy, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004 and Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567 2024. A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation. Cell Reports 43 (6) , 114259. 10.1016/j.celrep.2024.114259 |
Whiteside, Sarah K., Grant, Francis M., Alvisi, Giorgia, Clarke, James, Tang, Leqi, Imianowski, Charlotte J., Zhang, Baojie, Evans, Alexander C., Wesolowski, Alexander J., Conti, Alberto G., Yang, Jie, Lauder, Sarah N., Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Dooley, James, Burton, Oliver, Liston, Adrian, Alloisio, Marco, Voulaz, Emanuele, Langhorne, Jean, Okkenhaug, Klaus, Lugli, Enrico and Roychoudhuri, Rahul 2023. Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion. Science Immunology 8 (90) , eabo5558. 10.1126/sciimmunol.abo5558 |
Milutinovic, Stefan ORCID: https://orcid.org/0000-0002-3163-3383, Abe, Jun, Jones, Emma, Kelch, Inken, Smart, Kathryn, Lauder, Sarah N., Somerville, Michelle, Ware, Carl, Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567, Stein, Jens V., Bogle, Gib and Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004 2022. Three-dimensional imaging reveals immune-driven tumor-associated high endothelial venules as a key correlate of tumor rejection following depletion of regulatory T cells. Cancer Research Communications 2 (12) , pp. 1641-1656. 10.1158/2767-9764.CRC-21-0123 |
Lauder, Sarah N., Smart, Kathryn, Bart, Valentina M. T., Pires, Ana, Scott, Jake, Milutinovic, Stefan ORCID: https://orcid.org/0000-0002-3163-3383, Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567, Vanhaesebroeck, Bart and Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004 2022. Treg-driven tumour control by PI3Kδ inhibition limits myeloid-derived suppressor cell expansion. British Journal of Cancer 127 , 1595–1602. 10.1038/s41416-022-01917-0 |
Lauder, Sarah N., Vanhaesebroeck, Bart and Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004 2021. Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach. British Journal of Cancer 125 , pp. 467-469. 10.1038/s41416-021-01285-1 |
Lauder, S. N., Milutinovic, S. ORCID: https://orcid.org/0000-0002-3163-3383, Pires, A., Smart, K., Godkin, A. ORCID: https://orcid.org/0000-0002-1910-7567 and Gallimore, A. ORCID: https://orcid.org/0000-0001-6675-7004 2021. Using methylcholanthrene-induced fibrosarcomas to study tumor immunology. Methods in Cell Biology, Vol. 163. Elsevier, pp. 59-75. (10.1016/bs.mcb.2020.09.007) |
Pires, Ana, Greenshields Watson, Alexander, Jones, Emma, Smart, Kathryn, Lauder, Sarah N., Somerville, Michelle, Milutinovic, Stefan ORCID: https://orcid.org/0000-0002-3163-3383, Kendrick, Howard, Hindley, James P., French, Rhiannon, Smalley, Matthew J. ORCID: https://orcid.org/0000-0001-9540-1146, Watkins, William John ORCID: https://orcid.org/0000-0003-3262-6588, Andrews, Robert, Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567 and Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004 2020. Immune remodelling of the extracellular matrix drives loss of cancer stem cells and tumor rejection. Cancer Immunology Research 8 (12) , 1520 - 1531. 10.1158/2326-6066.CIR-20-0070 |
Hughes, Ellyn, Lauder, Sarah N., Smart, Kathryn, Bloom, Anja, Scott, Jake, Jones, Emma, Somerville, Michelle, Browne, Molly, Blainey, Andrew, Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004 2020. Primary breast tumours but not lung metastases induce protective anti-tumour immune responses after Treg-depletion. Cancer Immunology, Immunotherapy 69 , 2063 - 2073. 10.1007/s00262-020-02603-x |
Lauder, Sarah Nicol, Smart, Kathryn, Kersemans, Veerle, Allen, Danny, Scott, Jake, Pires, Ana, Milutinovic, Stefan ORCID: https://orcid.org/0000-0002-3163-3383, Somerville, Michelle, Smart, Sean, Kinchesh, Paul, Lopez-Guadamillas, Elena, Hughes, Ellyn, Jones, Emma, Scurr, Martin ORCID: https://orcid.org/0000-0002-4120-0688, Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567, Friedman, Lori S, Vanhaesebroeck, Bart and Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004 2020. Enhanced antitumor immunity through sequential targeting of PI3Kδ and LAG3. Journal for ImmunoTherapy of Cancer 8 (2) , e000693. 10.1136/jitc-2020-000693 |
Thomson, Amanda, Smart, Kathryn, Somerville, Michelle S., Lauder, Sarah N., Appanna, Gautham, Horwood, James, Lawrence-Sunder, Raj, Srivastava, Brijesh, Durai, Dhamaraj, Scurr, Martin J. ORCID: https://orcid.org/0000-0002-4120-0688, Keita, Asa V., Gallimore, Awen M. ORCID: https://orcid.org/0000-0001-6675-7004 and Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567 2019. The Ussing chamber system for measuring intestinal permeability in health and disease. BMC Gastroenterology 19 , 98. 10.1186/s12876-019-1002-4 |
Allen-Redpath, Keith, Aldrovandi, Maceler, Lauder, Sarah N., Gketsopoulou, Anastasia, Tyrrell, Victoria J., Slatter, David A., Andrews, Robert, Watkins, W. John ORCID: https://orcid.org/0000-0003-3262-6588, Atkinson, Georgia, McNeill, Eileen, Gilfedder, Anna, Protty, Majd, Burston, James, Johnson, Sam R. C., Rodrigues, Patricia R. S. ORCID: https://orcid.org/0000-0003-0768-0013, Jones, Dylan O., Lee, Regent, Handa, Ashok, Channon, Keith, Obaji, Samya, Alvarez-Jarreta, Jorge, Krönke, Gerhard, Ackermann, Jochen, Jenkins, P. Vince, Collins, Peter W. ORCID: https://orcid.org/0000-0002-6410-1324 and O'Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460 2019. Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity. Proceedings of the National Academy of Sciences 116 (16) , pp. 8038-8047. 10.1073/pnas.1814409116 |
Slatter, David A., Percy, Charles L., Allen-Redpath, Keith, Gajsiewicz, Joshua M., Brooks, Nick J., Clayton, Aled ORCID: https://orcid.org/0000-0002-3087-9226, Tyrrell, Victoria J., Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Lauder, Sarah N., Watson, Andrew, Dul, Maria ORCID: https://orcid.org/0000-0002-0192-2280, Garcia-Diaz, Yoel, Aldrovandi, Maceler, Heurich, Meike, Hall, Judith ORCID: https://orcid.org/0000-0002-6770-7372, Morrissey, James H., Lacroix-Desmazes, Sebastien, Delignat, Sandrine, Jenkins, P. Vincent, Collins, Peter W. ORCID: https://orcid.org/0000-0002-6410-1324 and O'Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460 2018. Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies. JCI Insight 3 (6) , e98459. 10.1172/jci.insight.98459 |
Zhao, Jingmin, Minami, Yoshinori, Etling, Emily, Coleman, John M., Lauder, Sarah, Tyrrell, Victoria, Aldrovandi, Maceler, O'Donnell, Valerie Bridget ORCID: https://orcid.org/0000-0003-4089-8460, Claesson, Hans-Erik, Kagan, Valerian and Wenzel, Sally 2017. Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology 57 (6) 10.1165/rcmb.2017-0031OC |
Aldrovandi, MacEler, Hinz, Christine, Lauder, Sarah N, Podmore, Helen, Hornshaw, Martin, Slatter, David A, Tyrrell, Victoria J, Clark, Stephen R, Marnett, Lawrence J., Collins, Peter W ORCID: https://orcid.org/0000-0002-6410-1324, Murphy, Robert C and O'Donnell, Valerie B ORCID: https://orcid.org/0000-0003-4089-8460 2017. DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression. Redox Biology 11 , pp. 663-672. 10.1016/j.redox.2017.01.001 |
Lauder, Sarah N., Tyrrell, Victoria J., Allen-Redpath, Keith, Aldrovandi, MacEler, Gray, David, Collins, Peter ORCID: https://orcid.org/0000-0002-6410-1324, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421 and O'Donnell, Valerie ORCID: https://orcid.org/0000-0003-4089-8460 2017. Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo. Wellcome Open Research 2 (1) 10.12688/wellcomeopenres.10308.1 |
Hinz, Christine, Aldrovandi, Maceler, Uhlson, Charis, Marnett, Lawrence J., Longhurst, Hilary J., Warner, Timothy D., Alam, Saydul, Slatter, David A., Lauder, Sarah N., Allen-Redpath, Keith, Collins, Peter W. ORCID: https://orcid.org/0000-0002-6410-1324, Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613 and O'Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460 2016. Human platelets utilize cycloxygenase-1 to generate dioxolane A3, a neutrophil activating eicosanoid. Journal of Biological Chemistry 291 (26) , pp. 13448-13464. 10.1074/jbc.M115.700609 |
Lauder, Sarah Nicol, Jones, Emma, Smart, Kathryn, Bloom, Anja Constanze, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Hindley, James P., Ondondo, Beatrice, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2013. Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology. European Journal of Immunology 43 (10) , pp. 2613-2625. 10.1002/eji.201243018 |
Hammond, Victoria Jayne, Morgan, Alwena H., Lauder, Sarah Nicol, Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613, Brown, Sarah, Freeman, Bruce A., Lloyd, Clare M., Davies, Jane, Bush, Andrew, Levonen, Anna-Liisa, Kansanen, Emilia, Villacorta, Luis, Chen, Y. Eugene, Porter, Ned, Garcia-Diaz, Yoel M., Schopfer, Francisco J. and O'Donnell, Valerie Bridget ORCID: https://orcid.org/0000-0003-4089-8460 2012. Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ. Journal of Biological Chemistry 287 (50) , pp. 41651-41666. 10.1074/jbc.M112.405407 |
Hindley, James Phillip, Jones, Emma, Smart, Kathryn, Bridgeman, Hayley, Lauder, Sarah Nicol, Ondondo, Beatrice Omusiro, Cutting, Scott, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Wynn, Katherine Kay, Withers, David, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2012. T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T cell depletion. Cancer Research 72 (21) , pp. 5473-5482. 10.1158/0008-5472.CAN-12-1912 |
Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Ekeruche, Julia, Miles, John James, Edwards, Emily ORCID: https://orcid.org/0000-0002-0240-4370, Dolton, Garry Michael, Williams, Tamsin, Schauenburg, Andrea J. A., Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Lauder, Sarah Nicol, Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Burrows, Scott R., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Wooldridge, Linda 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187 (2) , pp. 654-663. 10.4049/jimmunol.1003941 |
Hindley, James Philip, Ferreira, Cristina, Jones, Emma, Lauder, Sarah Nicol, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Wynn, Katherine, Betts, Gareth James, Singh, Yogesh, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Dyson, Julian and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2011. Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors. Cancer Research 71 (3) , pp. 736-746. 10.1158/0008-5472.CAN-10-1797 |
Page, Charlotte E., Smale, Shaun, Carty, Sara Madelaine, Amos, Nick, Lauder, Sarah Nicol, Goodfellow, Rhian Mair, Richards, Peter James, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Topley, Nicholas and Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X 2010. Interferon-γ inhibits interleukin-1β-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis. Arthritis Research & Therapy 12 (2) , R49. 10.1186/ar2960 |
Page, Charlotte E., Smale, Shaun, Carty, Sara Madelaine, Amos, Nick, Lauder, Sarah Nicol, Goodfellow, Rhian Mair, Richards, Peter J., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Topley, Nicholas and Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X 2010. Interferon-gamma inhibits interleukin-1 beta-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis. Arthritis Research and Therapy 12 (2) , R49. |
Gallagher, Kathleen M. E., Lauder, Sarah Nicol, Rees, Ian W., Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 and Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567 2009. Type I interferon (IFNα) acts directly on human memory CD4+ T cells altering their response to antigen. The Journal of Immunology 183 (5) , pp. 2915-2920. 10.4049/jimmunol.0801607 |
Longhi, Maria Paula, Wright, Kate Louise, Lauder, Sarah Nicol, Nowell, Mari Ann, Jones, Gareth Wyn, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2008. Interleukin-6 is crucial for recall of influenza-specific memory cd4+ t cells. PLoS Pathogens 4 (2) , e1000006. 10.1371/journal.ppat.1000006 |
Carty, Sara Madelaine, Nowell, Mari Ann, Lauder, Sarah Nicol, Goodfellow, Rhian Mair, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Williams, B. D. and Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X 2007. Combination therapy with etanercept and sgp130 for rheumatoid arthritis is more effective than monotherapy [Abstract]. Rheumatology 46 (s1) , I18-I18. 10.1093/rheumatology/kem1007 |
Page, Charlotte E., Smale, Shaun, Lauder, Sarah Nicol, Carty, Sara Madelaine and Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X 2007. Interferon gamma decreases interleukin 1 beta-mediated cartilage loss in rheumatoid arthritis [Abstract]. Rheumatology 46 , I45-I46. |
Bondeson, Jan, Lauder, Sarah Nicol, Wainwright, Shane Daniel, Amos, Nick, Evans, A., Hughes, Clare Elizabeth ORCID: https://orcid.org/0000-0003-4726-5877, Feldmann, M. and Caterson, Bruce ORCID: https://orcid.org/0000-0001-6016-0661 2007. Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent. The Journal of Rheumatology 34 (3) , pp. 523-533. |
Lauder, Sarah Nicol 2007. Investigating the role of NF-kappaB in the pathology of osteoarthritis. PhD Thesis, Cardiff University. |
Bondeson, Jan, Wainwright, Shane Daniel, Lauder, Sarah Nicol, Amos, Nick and Hughes, Clare Elizabeth ORCID: https://orcid.org/0000-0003-4726-5877 2006. The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis. Arthritis Research and Therapy 8 (6) , pp. 187-199. 10.1186/ar2099 |
Amos, Nick, Lauder, Sarah Nicol, Evans, A., Feldmann, M. and Bondeson, Jan 2006. Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent. Rheumatology 45 (10) , pp. 1201-1209. 10.1093/rheumatology/kel078 |