Gully, Benjamin S., Rossjohn, Jamie ![]() ![]() |
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Abstract
The γδ T cell immune cell lineage has remained relatively enigmatic and under-characterised since their identification. Conversely, the insights we have, highlight their central importance in diverse immunological roles and homeostasis. Thus, γδ T cells are considered as potentially a new translational tool in the design of new therapeutics for cancer and infectious disease. Here we review our current understanding of γδ T cell biology viewed through a structural lens centred on the how the γδ T cell receptor mediates ligand recognition. We discuss the limited knowledge of antigens, the structural basis of such reactivities and discuss the emerging trends of γδ T cell reactivity and implications for γδ T cell biology.
Item Type: | Article |
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Date Type: | Published Online |
Status: | Published |
Schools: | Medicine |
Additional Information: | This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) |
Publisher: | Portland Press |
ISSN: | 0300-5127 |
Date of First Compliant Deposit: | 7 October 2021 |
Date of Acceptance: | 19 August 2021 |
Last Modified: | 18 May 2023 19:14 |
URI: | https://orca.cardiff.ac.uk/id/eprint/144725 |
Citation Data
Cited 6 times in Scopus. View in Scopus. Powered By Scopus® Data
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