Linking the cortical microstructure to oscillatory dynamics through in vivo imaging

Bloomfield, Laura 2021. Linking the cortical microstructure to oscillatory dynamics through in vivo imaging. PhD Thesis, Cardiff University. Item availability restricted.

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Abstract

Uncovering the intricate relationship between the brain’s structure and function remains a fundamental goal of the neuroscience field. Significantly, recent advancesin the neuroimaging field are now allowing for the investigation of this relationship at the microstructural level, opening up a wealth of new research possibilities. Of particular interest, is the ability to probe the myelin content of the cortex non- invasively and with high resolution. Notably a close relationship is known to exist between the cyto and myelo architecture of the brain and converging lines of evidence point to the potential existence of a relationship between myelination of the cortical grey matter and electrophysiological responses. Of particular interest in this regard are neural oscillations, which have been widely implicated in a variety of cognitive processes and clinical conditions. Thus, this thesis seeks to explore the possibility of investigating the relationship between a key aspect of the cortical microstructure, namely its myelin content and oscillatory dynamics in-vivo, through the use of highresolution 7T MRI in combination with MEG. Ultimately, the novel insights gained through this approach could have important implications for the understanding of brain structure-function relationships in both health and disease

Item Type:	Thesis (PhD)
Date Type:	Completion
Status:	Unpublished
Schools:	Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology
Date of First Compliant Deposit:	22 October 2021
Date of Acceptance:	22 October 2021
Last Modified:	22 Oct 2022 01:30
URI:	https://orca.cardiff.ac.uk/id/eprint/145013

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