Sesquiterpene synthases: Passive catalysts or active players?

Miller, David James and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2012. Sesquiterpene synthases: Passive catalysts or active players? Natural Product Reports 29 (1) , pp. 60-71. 10.1039/c1np00060h

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Abstract

Sesquiterpene synthases catalyse the metal dependent turnover of farnesyl diphosphate to generate a class of natural products characterised by an enormous diversity in structure, stereochemistry, biological function and application. It has been proposed that these enzymes take a passive role in the reactions they catalyse and that they serve mostly as stereochemical templates, within which the reactions take place. Here, recent research into the structure and function of sesquiterpene synthases and the mechanisms of the reactions that they catalyse will be reviewed to suggest that these fascinating enzymes play multifaceted active roles in what are arguably the most complex biosynthetic reactions.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Cardiff Catalysis Institute (CCI) Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	Royal Society of Chemistry
ISSN:	0265-0568
Funders:	BBSRC, EPSRC
Last Modified:	18 Oct 2022 13:35
URI:	https://orca.cardiff.ac.uk/id/eprint/14511

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