Structures of the human SPAK and OSR1 conserved C-terminal (CCT) domains

Elvers, Karen T., Lipka-Lloyd, Magdalena, Trueman, Rebecca C., Bax, Benjamin D. ORCID: https://orcid.org/0000-0003-1940-3785 and Mehellou, Youcef ORCID: https://orcid.org/0000-0001-5720-8513 2022. Structures of the human SPAK and OSR1 conserved C-terminal (CCT) domains. ChemBioChem 23 (1) , e202100441. 10.1002/cbic.202100441

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Abstract

The inhibition of SPAK and OSR1 kinases binding to their upstream WNK kinases has been identified as a plausible strategy for inhibiting the WNK-activation of SPAK and OSR1 kinases. To facilitate the discovery of SPAK and OSR1 kinase inhibitors as potential therapeutics, we report the crystal structures of the highly conserved C-terminal domains of human SPAK and OSR1, which mediate the binding to, and activation, by their upstream WNK kinases.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Publisher:	Wiley-VCH Verlag
ISSN:	1439-4227
Date of First Compliant Deposit:	30 November 2021
Date of Acceptance:	2 November 2021
Last Modified:	14 Nov 2024 21:00
URI:	https://orca.cardiff.ac.uk/id/eprint/145824

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