Browse by Current Cardiff authors

Kocsy, Klaudia, Wilkinson, Harry, Felix-Ilemhenbhio, Favour, Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785, Van Agtmael, Tom, Azzouz, Mimoun and Majid, Arshad 2025. Gene editing for collagen disorders: current advances and future perspectives. Gene Therapy 10.1038/s41434-025-00560-7

Nicholls, Robert A., Morgan, Harry, Warren, Anna J., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Long, Fei, Murshudov, Garib N., Sutormin, Dmitry and Bax, Benjamin D. ORCID: https://orcid.org/0000-0003-1940-3785 2025. How do gepotidacin and zoliflodacin stabilize DNA-cleavage complexes with bacterial type IIA topoisomerases? 2. A single moving metal mechanism. International Journal of Molecular Sciences 26 (1) , 33. 10.3390/ijms26010033

Wever, Mark J.A., Scommegna, Francesca R., Egea-Rodriguez, Sara, Dehghani-Tafti, Saba, Brandao-Neto, Jose, Poisson, Jean-François, Helfrich, Iris, Antson, Alfred A., Rodeschini, Vincent, Bax, Ben ORCID: https://orcid.org/0000-0003-1940-3785, Roche, Didier and Sanders, Cyril M. 2024. Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1. Nucleic Acids Research 52 (20) , pp. 12616-12632. 10.1093/nar/gkae897

Byl, Jo Ann W., Mueller, Rudolf, Bax, Ben ORCID: https://orcid.org/0000-0003-1940-3785, Basarab, Gregory S., Chibale, Kelly and Osheroff, Neil 2023. A series of Spiropyrimidinetriones that enhances DNA cleavage mediated by Mycobacterium tuberculosis gyrase. ACS Infectious Diseases 9 (3) , pp. 706-715. 10.1021/acsinfecdis.3c00012

Morgan, Harry, Lipka-Lloyd, Magdalena, Warren, Anna J., Hughes, Naomi, Holmes, John, Burton, Nicolas P., Mahenthiralingam, Eshwar ORCID: https://orcid.org/0000-0001-9014-3790 and Bax, Ben D. ORCID: https://orcid.org/0000-0003-1940-3785 2023. A 2.8 Å structure of zoliflodacin in a DNA cleavage complex with staphylococcus aureus DNA gyrase. International Journal of Molecular Sciences 24 (2) , 1634. 10.3390/ijms24021634

Bax, Ben D. ORCID: https://orcid.org/0000-0003-1940-3785, Sutormin, Dmitry, McDonald, Neil Q., Burley, Glenn A. and Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309 2022. Oligonucleotide-recognizing topoisomerase inhibitors (OTIs): precision gene editors for neurodegenerative diseases. International Journal of Molecular Sciences 23 (19) , 11541. 10.3390/ijms231911541

Elvers, Karen T., Lipka-Lloyd, Magdalena, Trueman, Rebecca C., Bax, Benjamin D. ORCID: https://orcid.org/0000-0003-1940-3785 and Mehellou, Youcef ORCID: https://orcid.org/0000-0001-5720-8513 2022. Structures of the human SPAK and OSR1 conserved C-terminal (CCT) domains. ChemBioChem 23 (1) , e202100441. 10.1002/cbic.202100441

Fenn, Gareth, Waller-Evans, Helen ORCID: https://orcid.org/0000-0003-4133-6064, Atack, John R. ORCID: https://orcid.org/0000-0002-3410-791X and Bax, Benjamin D. ORCID: https://orcid.org/0000-0003-1940-3785 2020. Crystallization and structure of ebselen bound to cysteine 141 of human inositol monophosphatase (IMPase). Acta Crystallographica Section F: Structural Biology Communications F76 (10) , pp. 469-476. 10.1107/S2053230X20011310

Koulouris, Chloe R., Bax, Benjamin D. ORCID: https://orcid.org/0000-0003-1940-3785, Atack, John R. ORCID: https://orcid.org/0000-0002-3410-791X and Roe, S. Mark 2020. Conformational flexibility within the small domain of human serine racemase. Acta Crystallographica Section F: Structural Biology Communications 76 (2) , pp. 65-73. 10.1107/S2053230X20001193

Bax, Benjamin D. ORCID: https://orcid.org/0000-0003-1940-3785, Murshudov, Garib, Maxwell, Anthony and Germe, Thomas 2019. DNA Topoisomerase inhibitors: trapping a DNA-cleaving machine in motion. Journal of Molecular Biology 431 (18) , pp. 3427-3449. 10.1016/j.jmb.2019.07.008

Thalji, Reema K., Raha, Kaushik, Andreotti, Daniele, Checchia, Anna, Cui, Haifeng, Meneghelli, Giovanni, Profeta, Roberto, Tonelli, Federica, Tommasi, Simona, Bakshi, Tania, Donovan, Brian T., Howells, Alison, Jain, Shruti, Nixon, Christopher, Quinque, Geoffrey, McCloskey, Lynn, Bax, Benjamin D. ORCID: https://orcid.org/0000-0003-1940-3785, Neu, Margarete, Chan, Pan F. and Stavenger, Robert A. 2019. Structure-guided design of antibacterials that allosterically inhibit DNA gyrase. Bioorganic and Medicinal Chemistry Letters 29 (11) , pp. 1407-1412. 10.1016/j.bmcl.2019.03.029

Gibson, Elizabeth G, Bax, Ben ORCID: https://orcid.org/0000-0003-1940-3785, Chan, Pan F and Osheroff, Neil 2019. Mechanistic and structural basis for the actions of the antibacterial gepotidacin against Staphylococcus aureus gyrase. ACS Infectious Diseases 5 (4) , pp. 570-581. 10.1021/acsinfecdis.8b00315

Dehghani-Tafti, Saba, Levdikov, Vladimir, Antson, Alfred A., Bax, Ben ORCID: https://orcid.org/0000-0003-1940-3785 and Sanders, Cyril M. 2019. Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase. Nucleic Acids Research 47 (6) , pp. 3208-3222. 10.1093/nar/gkz028

Gibson, Elizabeth G., Blower, Tim R., Cacho, Monica, Bax, Ben ORCID: https://orcid.org/0000-0003-1940-3785, Berger, James M. and Osheroff, Neil 2018. Mechanism of action of mycobacterium tuberculosis gyrase Inhibitors: A novel class of gyrase poisons. ACS Infectious Diseases 4 (8) , p. 1211. 10.1021/acsinfecdis.8b00035

Germe, Thomas, Vörös, Judit, Jeannot, Frederic, Taillier, Thomas, Stavenger, Robert A, Bacqué, Eric, Maxwell, Anthony and Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785 2018. A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance. Nucleic Acids Research 46 (8) , pp. 4114-4128. 10.1093/nar/gky181

Lara, Lorena Infante, Fenner, Sabine, Ratcliffe, Steven, Isidro-Llobet, Albert, Hann, Michael, Bax, Ben ORCID: https://orcid.org/0000-0003-1940-3785 and Osheroff, Neil 2018. Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences. Nucleic Acids Research 46 (5) , pp. 2218-2233. 10.1093/nar/gky072

Henley, Zoë A., Bax, Benjamin D. ORCID: https://orcid.org/0000-0003-1940-3785, Inglesby, Laura M., Champigny, Aurélie, Gaines, Simon, Faulder, Paul, Le, Joelle, Thomas, Daniel A., Washio, Yoshiaki and Baldwin, Ian R. 2017. From PIM1 to PI3Kδ via GSK3β: Target hopping through the kinome. ACS Medicinal Chemistry Letters 8 (10) , pp. 1093-1098. 10.1021/acsmedchemlett.7b00296

Chan, Pan F., Germe, Thomas, Bax, Benjamin D. ORCID: https://orcid.org/0000-0003-1940-3785, Huang, Jianzhong, Thalji, Reema K., Bacqué, Eric, Checchia, Anna, Chen, Dongzhao, Cui, Haifeng, Ding, Xiao, Ingraham, Karen, McCloskey, Lynn, Raha, Kaushik, Srikannathasan, Velupillai, Maxwell, Anthony and Stavenger, Robert A. 2017. Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase. Proceedings of the National Academy of Sciences 114 (22) , E4492-E4500. 10.1073/pnas.1700721114

Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785, Chung, Chun-wa and Edge, Colin 2017. Getting the chemistry right: protonation, tautomers and the importance of H atoms in biological chemistry. Acta Crystallographica Section D Structural Biology 73 (2) , pp. 131-140. 10.1107/S2059798316020283

Miles, Timothy J., Hennessy, Alan J., Bax, Ben ORCID: https://orcid.org/0000-0003-1940-3785, Brooks, Gerald, Brown, Barry S., Brown, Pamela, Cailleau, Nathalie, Chen, Dongzhao, Dabbs, Steven, Davies, David T., Esken, Joel M., Giordano, Ilaria, Hoover, Jennifer L., Jones, Graham E., Kusalakumari Sukmar, Senthill K., Markwell, Roger E., Minthorn, Elisabeth A., Rittenhouse, Steve, Gwynn, Michael N. and Pearson, Neil D. 2016. Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases. Bioorganic and Medicinal Chemistry Letters 26 (10) , pp. 2464-2469. 10.1016/j.bmcl.2016.03.106

Chan, Pan F., Srikannathasan, Velupillai, Huang, Jianzhong, Cui, Haifeng, Fosberry, Andrew P., Gu, Minghua, Hann, Michael M., Hibbs, Martin, Homes, Paul, Ingraham, Karen, Pizzollo, Jason, Shen, Carol, Shillings, Anthony J., Spitzfaden, Claus E., Tanner, Robert, Theobald, Andrew J., Stavenger, Robert A., Bax, Benjamin D. ORCID: https://orcid.org/0000-0003-1940-3785 and Gwynn, Michael N. 2015. Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin. Nature Communications 6 , 10048. 10.1038/ncomms10048

Lewis, Huw D., Liddle, John, Coote, Jim E., Atkinson, Stephen J., Barker, Michael D., Bax, Benjamin D. ORCID: https://orcid.org/0000-0003-1940-3785, Bicker, Kevin L., Bingham, Ryan P., Campbell, Matthew, Chen, Yu Hua, Chung, Chun-wa, Craggs, Peter D., Davis, Rob P., Eberhard, Dirk, Joberty, Gerard, Lind, Kenneth E., Locke, Kelly, Maller, Claire, Martinod, Kimberly, Patten, Chris, Polyakova, Oxana, Rise, Cecil E, Rüdiger, Martin, Sheppard, Robert J., Slade, Daniel J., Thomas, Pamela, Thorpe, Jim, Yao, Gang, Drewes, Gerard, Wagner, Denisa D., Thompson, Paul R., Prinjha, Rab K. and Wilson, David M. 2015. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nature Chemical Biology 11 (3) , pp. 189-191. 10.1038/nchembio.1735

Slade, Daniel J., Fang, Pengfei, Dreyton, Christina J., Zhang, Ying, Fuhrmann, Jakob, Rempel, Don, Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785, Coonrod, Scott A., Lewis, Huw D., Guo, Min, Gross, Michael L. and Thompson, Paul R. 2015. Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design. ACS Chemical Biology 10 (4) , pp. 1043-1053. 10.1021/cb500933j

Srikannathasan, Velupillai, Wohlkonig, Alexandre, Shillings, Anthony, Singh, Onkar, Chan, Pan F., Huang, Jianzhong, Gwynn, Michael N., Fosberry, Andrew P., Homes, Paul, Hibbs, Martin, Theobald, Andrew J., Spitzfaden, Claus and Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785 2015. Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes ofStaphyloccocus aureusDNA gyrase with QPT-1, moxifloxacin and etoposide. Acta Crystallographica Section F Structural Biology Communications 71 (10) , pp. 1242-1246. 10.1107/S2053230X15015290

Li, Dianfan, Howe, Nicole, Dukkipati, Abhiram, Shah, Syed T. A., Bax, Benjamin D. ORCID: https://orcid.org/0000-0003-1940-3785, Edge, Colin, Bridges, Angela, Hardwicke, Phil, Singh, Onkar M. P., Giblin, Ged, Pautsch, Alexander, Pfau, Roland, Schnapp, Gisela, Wang, Meitian, Olieric, Vincent and Caffrey, Martin 2014. Crystallizing membrane proteins in the lipidic mesophase. Experience with human prostaglandin e2 synthase 1 and an evolving strategy. Crystal Growth and Design 14 (4) , pp. 2034-2047. 10.1021/cg500157x

Agrawal, Alka, Roué, Mélanie, Spitzfaden, Claus, Petrella, Stéphanie, Aubry, Alexandra, Hann, Michael, Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785 and Mayer, Claudine 2013. Mycobacterium tuberculosisDNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motion. Biochemical Journal 456 (2) , pp. 263-273. 10.1042/BJ20130538

Chan, Pan F., Huang, Jianzhong, Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785 and Gwynn, Michael N. 2013. Recent developments in inhibitors of bacterial type IIA topoisomerases. Gualerzi, Claudio O., Brandi, Letizia and Pon, Cynthia L., eds. Antibiotics: Targets, Mechanisms and Resistance, Wiley, p. 263. (10.1002/9783527659685.ch11)

Miles, Timothy J., Hennessy, Alan J., Bax, Ben ORCID: https://orcid.org/0000-0003-1940-3785, Brooks, Gerald, Brown, Barry S., Brown, Pamela, Cailleau, Nathalie, Chen, Dongzhao, Dabbs, Steven, Davies, David T., Esken, Joel M., Giordano, Ilaria, Hoover, Jennifer L., Huang, Jianzhong, Jones, Graham E., Kusalakumari Sukmar, Senthill K., Spitzfaden, Claus, Markwell, Roger E., Minthorn, Elisabeth A., Rittenhouse, Steve, Gwynn, Michael N. and Pearson, Neil D. 2013. Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases. Bioorganic and Medicinal Chemistry Letters 23 (19) , pp. 5437-5441. 10.1016/j.bmcl.2013.07.013

Roué, Mélanie, Agrawal, Alka, Volker, Craig, Mossakowska, Danuta, Mayer, Claudine and Bax, Benjamin D. ORCID: https://orcid.org/0000-0003-1940-3785 2013. Purification, crystallization and preliminary X-ray crystallographic studies of the Mycobacterium tuberculosis DNA gyrase ATPase domain. Acta Crystallographica Section F F69 (6) , pp. 679-682. 10.1107/S1744309113012906

Gentile, Gabriella, Merlo, Giancarlo, Pozzan, Alfonso, Bernasconi, Giovanni, Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785, Bamborough, Paul, Bridges, Angela, Carter, Paul, Neu, Margarete, Yao, Gang, Brough, Caroline, Cutler, Geoffrey, Coffin, Aaron and Belyanskaya, Svetlana 2012. 5-Aryl-4-carboxamide-1,3-oxazoles: Potent and selective GSK-3 inhibitors. Bioorganic and Medicinal Chemistry Letters 22 (5) , pp. 1989-1994. 10.1016/j.bmcl.2012.01.034

Gentile, Gabriella, Bernasconi, Giovanni, Pozzan, Alfonso, Merlo, Giancarlo, Marzorati, Paola, Bamborough, Paul, Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785, Bridges, Angela, Brough, Caroline, Carter, Paul, Cutler, Geoffrey, Neu, Margarete and Takada, Mia 2011. Identification of 2-(4-pyridyl)thienopyridinones as GSK-3β inhibitors. Bioorganic and Medicinal Chemistry Letters 21 (16) , pp. 4823-4827. 10.1016/j.bmcl.2011.06.050

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Harries, Mark, Aldegheri, Laura, Austin, Nigel E., Ballantine, Stuart, Ballini, Elisa, Bradley, Daniel M., Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785, Clarke, Brian P., Harris, Andrew J., Harrison, Stephen A., Melarange, Rosemary A., Mookherjee, Claudette, Mosley, Julie, Dal Negro, Gianni, Oliosi, Beatrice, Smith, Kathrine J., Thewlis, Kevin M., Woollard, Patrick M. and Yusaf, Shahnaz P. 2011. Integration of lead optimization with crystallography for a membrane-bound ion channel target: discovery of a new class of AMPA receptor positive allosteric modulators. Journal of Medicinal Chemistry 54 (1) , pp. 78-94. 10.1021/jm100679e

Wohlkonig, Alexandre, Chan, Pan F, Fosberry, Andrew P, Homes, Paul, Huang, Jianzhong, Kranz, Michael, Leydon, Vaughan R, Miles, Timothy J, Pearson, Neil D, Perera, Rajika L, Shillings, Anthony J, Gwynn, Michael N and Bax, Benjamin D ORCID: https://orcid.org/0000-0003-1940-3785 2010. Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance. Nature Structural and Molecular Biology 17 (99) , pp. 1152-1153. 10.1038/nsmb.1892

Bax, Benjamin D. ORCID: https://orcid.org/0000-0003-1940-3785, Chan, Pan F., Eggleston, Drake S., Fosberry, Andrew, Gentry, Daniel R., Gorrec, Fabrice, Giordano, Ilaria, Hann, Michael M., Hennessy, Alan, Hibbs, Martin, Huang, Jianzhong, Jones, Emma, Jones, Jo, Brown, Kristin Koretke, Lewis, Ceri J., May, Earl W., Saunders, Martin R., Singh, Onkar, Spitzfaden, Claus E., Shen, Carol, Shillings, Anthony, Theobald, Andrew J., Wohlkonig, Alexandre, Pearson, Neil D. and Gwynn, Michael N. 2010. Type IIA topoisomerase inhibition by a new class of antibacterial agents. Nature 466 (7309) , pp. 935-940. 10.1038/nature09197

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Harries, Mark, Aldegheri, Laura, Andreotti, Daniele, Ballantine, Stuart, Bax, Benjamin D. ORCID: https://orcid.org/0000-0003-1940-3785, Harris, Andrew J., Harker, Andy J., Lund, Jesper, Melarange, Rosemary, Mingardi, Anna, Mookherjee, Claudette, Mosley, Julie, Neve, Marta, Oliosi, Beatrice, Profeta, Roberto, Smith, Kathrine J., Smith, Paul W., Spada, Simone, Thewlis, Kevin M. and Yusaf, Shahnaz P. 2010. Discovery of N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator. Journal of Medicinal Chemistry 53 (15) , pp. 5801-5812. 10.1021/jm1005429

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Bax, Benjamin D. ORCID: https://orcid.org/0000-0003-1940-3785 and Harries, Mark 2010. Challenges for and current status of research into positive modulators of AMPA receptors. British Journal of Pharmacology 160 (2) , pp. 181-190. 10.1111/j.1476-5381.2010.00726.x

Christopher, John A., Atkinson, Francis L., Bax, Benjamin D. ORCID: https://orcid.org/0000-0003-1940-3785, Brown, Murray J.B., Champigny, Aurélie C., Chuang, Tsu Tshen, Jones, Emma J., Mosley, Julie E. and Musgrave, James R. 2009. 1-Aryl-3,4-dihydroisoquinoline inhibitors of JNK3. Bioorganic and Medicinal Chemistry Letters 19 (8) , pp. 2230-2234. 10.1016/j.bmcl.2009.02.098

Smith, Kathrine J, Carter, Paul S, Bridges, Angela, Horrocks, Pete, Lewis, Ceri, Pettman, Gary, Clarke, Andrew, Brown, Murray, Hughes, Jane, Wilkinson, Marc, Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785 and Reith, Alastair 2004. The structure of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein. Structure 12 (6) , pp. 1067-1077. 10.1016/j.str.2004.02.040

Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785, Carter, Paul S., Lewis, Ceri, Guy, Angela R., Bridges, Angela, Tanner, Robert, Pettman, Gary, Mannix, Chris, Culbert, Ainsley A., Brown, Murray J.B., Smith, David G. and Reith, Alastair D. 2001. The structure of phosphorylated GSK-3β complexed with a peptide, FRATtide, that inhibits β-catenin phosphorylation. Structure 9 (12) , pp. 1143-1152. 10.1016/S0969-2126(01)00679-7

Culbert, Ainsley A., Brown, Murray J., Frame, Sheelagh, Hagen, Thilo, Cross, Darren A.E., Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785 and Reith, Alastair D. 2001. GSK‐3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and β‐catenin stabilisation without elevation of glycogen synthase activity. FEBS Letters 507 (3) , pp. 288-294. 10.1016/S0014-5793(01)02990-8

Tisi, Dominic, Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785 and Loew, Andreas 2001. The three-dimensional structure of cytosolic bovine retinal creatine kinase. Acta Crystallographica Section D: Biological Crystallography 57 (2) , pp. 187-193. 10.1107/S0907444900015614

Yarski, Michael A, Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785, Hogue-Angeletti, Ruth A and Bradshaw, Ralph A 2000. Nerve growth factor α subunit: effect of site-directed mutations on catalytic activity and 7S NGF complex formation. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1477 (1-2) , pp. 253-266. 10.1016/S0167-4838(99)00277-0

Jones, David H., Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785, Fensome, Amanda and Cockcroft, Shamshad 1999. ADP ribosylation factor 1 mutants identify a phospholipase D effector region and reveal that phospholipase D participates in lysosomal secretion but is not sufficient for recruitment of coatomer I. Biochemical Journal 341 (1) , pp. 185-192. 10.1042/bj3410185

Loew, Andreas, Ho, Yee-Kin, Blundell, Tom and Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785 1998. Phosducin induces a structural change in transducin ?? Structure 6 (8) , pp. 1007-1019. 10.1016/S0969-2126(98)00102-6

Loew, A. and Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785 1998. Purification, crystallization and preliminary crystallographic analysis of bovine cytosolic brain-type creatine kinase. Acta Crystallographica Section D Biological Crystallography 54 (5) , pp. 989-990. 10.1107/S0907444998000985

Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785, Blundell, Tom L, Murray-Rust, Judith and McDonald, Neil Q 1997. Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins. Structure 5 (10) , pp. 1275-1285. 10.1016/S0969-2126(97)00280-3

Slingsby, C., Norledge, B., Simpson, A., Bateman, O.A., Wright, G., Driessen, H.P.C., Lindley, P.F., Moss, D.S. and Bax, B. ORCID: https://orcid.org/0000-0003-1940-3785 1997. X-ray diffraction and structure of crystallins. Progress in Retinal and Eye Research 16 (1) , pp. 3-29. 10.1016/S1350-9462(96)00018-3

Tisi, D., Teahan, C., Greasley, S., Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785, Neu, M. and Jhoti, H. 1997. Common themes and surprising differences in small G-proteins. Biochemical Society Transactions 25 (3) , pp. 989-991. 10.1042/bst0250989

Srinivasan, N., Bax, B. ORCID: https://orcid.org/0000-0003-1940-3785, Blundell, T.L. and Parker, P.J. 1996. Structural aspects of the functional modules in human protein kinase-Cα deduced from comparative analyses. Proteins 26 (2) , pp. 217-235. 10.1002/(SICI)1097-0134(199610)26:2<217::AID-PROT11>3.0.CO;2-S

Zaitseva, Irina, Zaitsev, Vjacheslav, Card, Graeme, Moshkov, Kirill, Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785, Ralph, Adam and Lindley, Peter 1996. The X-ray structure of human serum ceruloplasmin at 3.1.Å: nature of the copper centres. JBIC Journal of Biological Inorganic Chemistry 1 (1) , pp. 15-23. 10.1007/s007750050018

Bax, Ben ORCID: https://orcid.org/0000-0003-1940-3785 and Jhoti, Harren 1995. Protein-protein interactions: putting the pieces together. Current Biology 5 (10) , pp. 1119-1121. 10.1016/S0960-9822(95)00226-0

Greasley, Samantha E., Jhoti, Harren, Teahan, Carmel, Solari, Roberto, Fensome, Amanda, Thomas, Geraint M H, Cockcroft, Shamshad and Bax, Ben ORCID: https://orcid.org/0000-0003-1940-3785 1995. The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms. Nature Structural and Molecular Biology 2 (9) , pp. 797-806. 10.1038/nsb0995-797

Nalini, V., Bax, B. ORCID: https://orcid.org/0000-0003-1940-3785, Driessen, H., Moss, D.S., Lindley, P.F. and Slingsby, C. 1994. Close packing of an oligomeric eye lens β-crystallin induces loss of symmetry and ordering of sequence extensions. Journal of Molecular Biology 236 (4) , pp. 1250-1258. 10.1016/0022-2836(94)90025-6

Dhand, R., Hara, K., Hiles, I., Bax, B. ORCID: https://orcid.org/0000-0003-1940-3785, Gout, I., Panayotou, G., Fry, M.J., Yonezawa, K., Kasuga, M. and Waterfield, M.D. 1994. PI 3-kinase: structural and functional analysis of intersubunit interactions. EMBO Journal 13 (3) , pp. 511-521. 10.1002/j.1460-2075.1994.tb06289.x

Greasley, Samantha, Jhoti, Harren, Fensome, Amanda C., Cockcroft, Shamshad, Thomas, Geraint M.H. and Bax, Ben ORCID: https://orcid.org/0000-0003-1940-3785 1994. Crystallization and Preliminary X-ray Diffraction Studies on ADP-ribosylation Factor 1. Journal of Molecular Biology 244 (5) , pp. 651-653. 10.1006/jmbi.1994.1759

Bax, Ben ORCID: https://orcid.org/0000-0003-1940-3785, Ferguson, Geraldine, Blaber, Michael, Sternberg, Michael J. E. and Walls, Peter H. 1993. Prediction of the three-dimensional structures of the nerve growth factor and epidermal growth factor binding proteins (kallikreins) and an hypothetical structure of the high molecular weight complex of epidermal growth factor with its binding protein. Protein Science 2 (8) , pp. 1229-1241. 10.1002/pro.5560020805

Panayotou, G., Bax, B. ORCID: https://orcid.org/0000-0003-1940-3785, Gout, I., Federwisch, M., Wroblowski, B., Dhand, R., Fry, M.J., Blundell, T.L., Wollmer, A. and Waterfield, M.D. 1992. Interaction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes. EMBO Journal 11 (12) , pp. 4261-4272. 10.1002/j.1460-2075.1992.tb05524.x

Lapatto, R., Nalini, V., Bax, B. ORCID: https://orcid.org/0000-0003-1940-3785, Driessen, H., Lindley, P.F., Blundell, T.L. and Slingsby, C. 1991. High resolution structure of an oligomeric eye lens β-crystallin: Loops, arches, linkers and interfaces in βB2 dimer compared to a monomeric γ-crystallin. Journal of Molecular Biology 222 (4) , pp. 1067-1083. 10.1016/0022-2836(91)90594-V

Driessen, H. P. C., Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785, Slingsby, C., Lindley, P. F., Mahadevan, D., Moss, D. S. and Tickle, I. J. 1991. Structure of Oligomeric β B2-crystallin: an application of the T2 translation function to an asymmetric unit containing two dimers. Acta Crystallographica Section B: Structural Science 47 (6) , pp. 987-997. 10.1107/S0108768191009163

Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785, Lapatto, R., Nalini, V., Driessen, H., Lindley, P. F., Mahadevan, D., Blundell, T. L. and Slingsby, C. 1990. X-ray analysis of βB2-crystallin and evolution of oligomeric lens proteins. Nature 347 (6295) , pp. 776-780. 10.1038/347776a0

Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785 and Slingsby, C. 1989. Crystallization of a new form of the eye lens protein βB2-crystallin. Journal of Molecular Biology 208 (4) , pp. 715-717. 10.1016/0022-2836(89)90162-9

Slingsby, C., Driessen, H.P.C., Mahadevan, D., Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785 and Blundell, T.L. 1988. Evolutionary and functional relationships between the basic and acidic β-crystallins. Experimental Eye Research 46 (3) , pp. 375-403. 10.1016/S0014-4835(88)80027-7

Luchin, S.V., Zinovieva, R.D., Tomarev, S.I., Dolgilevich, S.M., Gause, G.G., Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785, Driessen, H. and Blundell, T.L. 1987. Frog lens βA1-crystallin: the nucleotide sequence of the cloned cDNA and computer graphics modelling of the three-dimensional structure. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 916 (2) , pp. 163-171. 10.1016/0167-4838(87)90104-X