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Structures of the human SPAK and OSR1 conserved C-terminal (CCT) domains

Elvers, Karen T., Lipka-Lloyd, Magdalena, Trueman, Rebecca C., Bax, Benjamin D. ORCID: and Mehellou, Youcef ORCID: 2022. Structures of the human SPAK and OSR1 conserved C-terminal (CCT) domains. ChemBioChem 23 (1) , e202100441. 10.1002/cbic.202100441

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The inhibition of SPAK and OSR1 kinases binding to their upstream WNK kinases has been identified as a plausible strategy for inhibiting the WNK-activation of SPAK and OSR1 kinases. To facilitate the discovery of SPAK and OSR1 kinase inhibitors as potential therapeutics, we report the crystal structures of the highly conserved C-terminal domains of human SPAK and OSR1, which mediate the binding to, and activation, by their upstream WNK kinases.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Publisher: Wiley-VCH Verlag
ISSN: 1439-4227
Date of First Compliant Deposit: 30 November 2021
Date of Acceptance: 2 November 2021
Last Modified: 17 Nov 2023 21:59

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