Topical therapy with negative allosteric modulators of the calcium-sensing receptor (calcilytics) for the management of asthma: the beginning of a new era?

Riccardi, Daniela ORCID: https://orcid.org/0000-0002-7322-3163, Ward, Jeremy P.T., Yarova, Polina L., Janssen, Luke J., Lee, Tak Hong, Ying, Sun and Corrigan, Chris J. 2022. Topical therapy with negative allosteric modulators of the calcium-sensing receptor (calcilytics) for the management of asthma: the beginning of a new era? European Respiratory Journal 60 (2) , 2102103. 10.1183/13993003.02103-2021

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Abstract

In this review article we present the evidence to date supporting the role of the calcium-sensing receptor (CaSR) as a key, pluripotential molecular trigger for asthma and speculate on the likely benefits of topical therapy of asthma with negative allosteric modulators of the CaSR: calcilytics.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	European Respiratory Society
ISSN:	0903-1936
Date of First Compliant Deposit:	16 February 2022
Date of Acceptance:	15 December 2021
Last Modified:	07 Nov 2023 07:26
URI:	https://orca.cardiff.ac.uk/id/eprint/147559

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