van Niel, Guillaume, Carter, David R. F., Clayton, Aled ![]() |
Preview |
PDF
- Accepted Post-Print Version
Download (503kB) | Preview |
Abstract
Extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication. They have important roles in numerous physiological and pathological processes, and show considerable promise as novel biomarkers of disease, as therapeutic agents and as drug delivery vehicles. Intriguingly, however, understanding of the cellular and molecular mechanisms that govern the many observed functions of EVs remains far from comprehensive, at least partly due to technical challenges in working with these small messengers. Here, we highlight areas of consensus as well as contentious issues in our understanding of the intracellular and intercellular journey of EVs: from biogenesis, release and dynamics in the extracellular space, to interaction with and uptake by recipient cells. We define knowledge gaps, identify key questions and challenges, and make recommendations on how to address these.
Item Type: | Article |
---|---|
Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Publisher: | Nature Research |
ISSN: | 1471-0072 |
Date of First Compliant Deposit: | 26 April 2022 |
Date of Acceptance: | 25 January 2022 |
Last Modified: | 05 Dec 2024 05:45 |
URI: | https://orca.cardiff.ac.uk/id/eprint/149367 |
Citation Data
Cited 51 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
![]() |
Edit Item |