Challenges and directions in studying cell-cell communication by extracellular vesicles

van Niel, Guillaume, Carter, David R. F., Clayton, Aled ORCID: https://orcid.org/0000-0002-3087-9226, Lambert, Daniel W., Raposo, Graça and Vader, Pieter 2022. Challenges and directions in studying cell-cell communication by extracellular vesicles. Nature Reviews Molecular Cell Biology 23 , 369–382. 10.1038/s41580-022-00460-3

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Abstract

Extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication. They have important roles in numerous physiological and pathological processes, and show considerable promise as novel biomarkers of disease, as therapeutic agents and as drug delivery vehicles. Intriguingly, however, understanding of the cellular and molecular mechanisms that govern the many observed functions of EVs remains far from comprehensive, at least partly due to technical challenges in working with these small messengers. Here, we highlight areas of consensus as well as contentious issues in our understanding of the intracellular and intercellular journey of EVs: from biogenesis, release and dynamics in the extracellular space, to interaction with and uptake by recipient cells. We define knowledge gaps, identify key questions and challenges, and make recommendations on how to address these.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Nature Research
ISSN:	1471-0072
Date of First Compliant Deposit:	26 April 2022
Date of Acceptance:	25 January 2022
Last Modified:	06 Nov 2023 16:35
URI:	https://orca.cardiff.ac.uk/id/eprint/149367

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