New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease

O'Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460 2022. New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease. Biochemical Society Transactions 50 (1) , pp. 1-11. 10.1042/BST20210579

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Abstract

The Lands Pathway is a fundamental biochemical process named for its discovery by William EM Lands and revealed in a series of seminal papers published in the Journal of Biological Chemistry between 1958–65. It describes the selective placement in phospholipids of acyl chains, by phospholipid acyltransferases. This pathway has formed a core component of our knowledge of phospholipid and also diglyceride metabolism in mammalian tissues for over 60 years now. Our understanding of how the Lands pathways are enzymatically mediated via large families of related gene products that display both substrate and tissue specificity has grown exponentially since. Recent studies building on this are starting to reveal key roles for the Lands pathway in specific scenarios, in particular inflammation, immunity and inflammation. This review will cover the Lands cycle from historical perspectives first, then present new information on how this important cycle forms a central regulatory node connecting fatty acyl and phospholipid metabolism and how its altered regulation may present new opportunities for therapeutic intervention in human disease.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Additional Information:	This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
Publisher:	Portland Press
ISSN:	0300-5127
Funders:	Wellcome Trust
Date of First Compliant Deposit:	20 July 2022
Date of Acceptance:	15 February 2022
Last Modified:	04 Sep 2023 16:28
URI:	https://orca.cardiff.ac.uk/id/eprint/151385

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