Loss-of-function ROX1 mutations suppress the fluconazole susceptibility of upc2AΔ mutation in Candida glabrata, implicating additional positive regulators of Ergosterol biosynthesis

Olinger, Tomye L., Vu, Bao, Murante, Daniel, Parker, Josie E., Simonica, Lucia, Doorley, Laura, Stammes, Mark A., Kelly, Steven L., Rogers, P. David, Moye-Rowley, Scott and Krysan, Damien J. 2021. Loss-of-function ROX1 mutations suppress the fluconazole susceptibility of upc2AΔ mutation in Candida glabrata, implicating additional positive regulators of Ergosterol biosynthesis. mSphere 6 (6) , e00830-21. 10.1128/msphere.00830-21

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Abstract

Candida glabrata is one of the most important human fungal pathogens and has reduced susceptibility to azole-class inhibitors of ergosterol biosynthesis. Although ergosterol is the target of two of the three classes of antifungal drugs, relatively little is known about the regulation of this critical cellular pathway.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	American Society for Microbiology
ISSN:	2379-5042
Date of First Compliant Deposit:	17 November 2022
Date of Acceptance:	1 December 2021
Last Modified:	27 May 2023 16:23
URI:	https://orca.cardiff.ac.uk/id/eprint/153111

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