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Number of items: 31.

Navarro-Mendoza, Maria Isabel, Perez-Arques, Carlos, Parker, Josie, Xu, Ziyan, Kelly, Stephen and Heitman, Joseph 2024. Alternative ergosterol biosynthetic pathways confer antifungal drug resistance in the human pathogens within the Mucor species complex. mBio 15 (8) , e01661-24. 10.1128/mbio.01661-24
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O'Connor-Moneley, James, Fletcher, Jessica, Bean, Cody, Parker, Josie, Kelly, Steven L., Moran, Gary P. and Sullivan, Derek J. 2024. Deletion of the Candida albicans TLO gene family results in alterations in membrane sterol composition and fluconazole tolerance. PLoS ONE 19 (8) , e0308665.. 10.1371/journal.pone.0308665
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Xie, Jinhong, Ryback, Jeffrey M., Martin-Vicente, Adela, Guruceaga, Xabier, Thorn, Harrison I., Nywening, Ashley V., Ge, Wenbo, Parker, Josie E., Kelly, Steven L., Rogers, David P. and Fortwendel, Jarrod R. 2024. The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus species. Nature Communications 15 , 4261. 10.1038/s41467-024-48767-3
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Rybak, Jeffrey M., Xie, Jinhong, Martin-Vincente, Adela, Guruceaga, Xabier, Thorn, Harrison I., Nywening, Ashley V., Ge, Wenbo Ge, Souza, Ana C. O., Shetty, Amol C., McCracken, Carrie, Bruno, Vincent M., Parker, Josie E., Kelly, Steven L., Snell, Hannah M., Cuomo, Christina A., Rogers, P. David and Fontwendel, Jarrod R. 2024. A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1. Nature Communications 15 , 3642. 10.1038/s41467-024-48029-2
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Ollinger, Tomye L., Zarnowski, Robert, Parker, Josie E., Kelly, Steven L., Andes, David R., Stamnes, Mark A. and Krysan, Damian J. 2024. Genetic interaction analysis of Candida glabrata transcription factors CST6 and UPC2A in the regulation of respiration and fluconazole susceptibility. Antimicrobial Agents and Chemotherapy
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Asadzadeh, Mohammad, Alfouzan, Wadha, Parker, Josie E., Meis, Jacques F., Kelly, Steven L., Joseph, Leena, Ahmad, Suhail and Alanio, Alexandre 2023. Molecular characterization and sterol profiles identify nonsynonymous mutations in ERG2 as a major mechanism conferring reduced susceptibility to amphotericin B in candida kefyr. Microbiology Spectrum 11 (4) , e01474-23. 10.1128/spectrum.01474-23
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Rybak, Jeffrey M., Barker, Katherine S., Muñoz, José F., Parker, Josie E., Ahmad, Suhail, Mokaddas, Eiman, Abdullah, Aneesa, Elhagracy, Rehab S., Kelly, Steve L., Cuomo, Christina A. and Rogers, P. David 2022. In vivo emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in Candida auris. Clinical Microbiology and Infection 28 (6) , pp. 838-843. 10.1016/j.cmi.2021.11.024

Regan, Jessica, DeJarnette, Christian, Luna-Tapia, Arturo, Parker, Josie E., Reitler, Parker, Barnett, Stacey, Tucker, Katie M., Kelly, Steven L and Palmer, Glen E 2022. Titration of C-5 Sterol Desaturase Activity Reveals Its Relationship to Candida albicans Virulence and Antifungal Susceptibility Is Dependent upon Host Immune Status. mBio 13 (2) 10.1128/mbio.00115-22
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Price, Claire L., Warrilow, Andrew G.S., Rolley, Nicola J, Parker, Josie, Thoss, Vera, Kelly, Diane E, Corcionivoschi, Nicolae and Kelly, Steven L 2022. Cytochrome P450 168A1 from pseudomonas aeruginosa is involved in the hydroxylation of biologically relevant fatty acids. PLoS ONE 17 (3) , pp. 1-20. 10.1371/journal.pone.0265227
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Olinger, Tomye L., Vu, Bao, Murante, Daniel, Parker, Josie E., Simonica, Lucia, Doorley, Laura, Stammes, Mark A., Kelly, Steven L., Rogers, P. David, Moye-Rowley, Scott and Krysan, Damien J. 2021. Loss-of-function ROX1 mutations suppress the fluconazole susceptibility of upc2AΔ mutation in Candida glabrata, implicating additional positive regulators of Ergosterol biosynthesis. mSphere 6 (6) , e00830-21. 10.1128/msphere.00830-21
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Luna-Tapia, Arturo, Parker, Josie E., Kelly, Steven L. and Palmer, Glen E. 2021. Species-specific differences in C-5 sterol desaturase function influence the outcome of azole antifungal exposure. Antimicrobial Agents and Chemotherapy 65 (12) , e01044. 10.1128/aac.01044-21
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Aruanno, Marion, Gozel, Samantha, Mouyna, Isabelle, Parker, Josie E., Bachmann, Daniel, Flament, Patricia, Coste, Alix T., Sanglard, Dominique and Lamoth, Frederic 2021. Insights in the molecular mechanisms of an azole stress adapted laboratory-generated Aspergillus fumigatus strain. Medical Mycology 59 (8) , pp. 763-772. 10.1093/mmy/myaa118

Binjubair, Faizah A., Parker, Josie E., Warrilow, Andrew G., Puri, Kalika, Braidley, Peter J., Tatar, Esra, Kelly, Steven L., Kelly, Diane E. and Simons, Claire ORCID: https://orcid.org/0000-0002-9487-1100 2020. Small‐molecule inhibitors targeting sterol 14α‐Demethylase (CYP51): synthesis, molecular modelling and evaluation against Candida albicans. ChemMedChem 15 (14) , pp. 1294-1309. 10.1002/cmdc.202000250
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Rybak, Jeffrey M., Muñoz, José F., Barker, Katherine S., Parker, Josie E., Esquivel, Brooke D., Berkow, Elizabeth L., Lockhart, Shawn R., Gade, Lalitha, Palmer, Glen E., White, Theodore C., Kelly, Steve L., Cuomo, Christina A., Rogers, P. David and Berman, Judith 2020. Mutations in TAC1B: a novel genetic determinant of clinical fluconazole resistance in Candida auris. mBio 11 (3) , e00365-20. 10.1128/mBio.00365-20
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Morgan, Sian R., Pilia, Nicole, Hewitt, Melissa, Moses, Rachael L., Moseley, Ryan ORCID: https://orcid.org/0000-0002-2812-6735, Lewis, Philip N. ORCID: https://orcid.org/0000-0002-3353-0708, Morrison, Peter W. J. ORCID: https://orcid.org/0000-0002-3712-7908, Kelly, Steven L., Parker, Josie E., Whitaker, David ORCID: https://orcid.org/0000-0002-8271-7552, Quantock, Andrew J. ORCID: https://orcid.org/0000-0002-2484-3120 and Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777 2020. Controlled in vitro delivery of voriconazole and diclofenac to the cornea using contact lenses for the treatment of Acanthamoeba keratitis. International Journal of Pharmaceutics 579 , 119102. 10.1016/j.ijpharm.2020.119102
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Furukawa, Takanori, van Rhijn, Norman, Fraczek, Marcin, Gsaller, Fabio, Davies, Emma, Carr, Paul, Gago, Sara, Fortune-Grant, Rachael, Rahman, Sayema, Gilsenan, Jane Mabey, Houlder, Emma, Kowalski, Caitlin H., Raj, Shriya, Paul, Sanjoy, Cook, Peter, Parker, Josie E., Kelly, Steve, Cramer, Robert A., Latgé, Jean-Paul, Moye-Rowley, Scott, Bignell, Elaine, Bowyer, Paul and Bromley, Michael J. 2020. The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus. Nature Communications 11 (1) , 427. 10.1038/s41467-019-14191-1
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Kannan, Abhilash, Asner, Sandra A., Trachsel, Emilie, Kelly, Steve, Parker, Josie, Sanglard, Dominique and Heitman, Joseph 2019. Comparative genomics for the elucidation of multidrug resistance in Candida lusitaniae. mBio 10 (6) , e02512-19. 10.1128/mBio.02512-19
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Warrilow, Andrew G.S., Parker, Josie E., Price, Claire L., Rolley, Nicola J., Nes, W. David, Kelly, Diane E. and Kelly, Steven L. 2019. Isavuconazole and voriconazole inhibition of sterol 14α-demethylases (CYP51) from Aspergillus fumigatus and Homo sapiens. International Journal of Antimicrobial Agents 54 (4) , pp. 449-455. 10.1016/j.ijantimicag.2019.07.011

Rybak, Jeffrey M., Ge, Wenbo, Wiederhold, Nathan P., Parker, Josie E., Kelly, Steven L., Rogers, P. David, Fortwendel, Jarrod R. and Alspaugh, J. Andrew 2019. Mutations in hmg1, challenging the paradigm of clinical triazole resistance in Aspergillus fumigatus. mBio 10 (2) , e00437-19. 10.1128/mBio.00437-19
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Warrilow, Andrew G., Nishimoto, Andrew T., Parker, Josie E., Price, Claire L., Flowers, Stephanie A., Kelly, Diane E., Rogers, P. David and Kelly, Steven L. 2019. The evolution of azole resistance in Candida albicans sterol 14α-demethylase (CYP51) through incremental amino acid substitutions. Antimicrobial Agents and Chemotherapy 63 (5) , e02586-18. 10.1128/AAC.02586-18
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Griffiths, William J., Crick, Peter J., Meljon, Anna, Theofilopoulos, Spyridon, Abdel-Khalik, Jonas, Yutuc, Eylan, Parker, Josie E., Kelly, Diane E., Kelly, Steven L., Arenas, Ernest and Wang, Yuqin 2019. Additional pathways of sterol metabolism: evidence from analysis of Cyp27a1-/- mouse brain and plasma. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1864 (2) , pp. 191-211. 10.1016/j.bbalip.2018.11.006

Ahmad, Suhail, Joseph, Leena, Parker, Josie E., Asadzadeh, Mohammad, Kelly, Steven L., Meis, Jacques F. and Khan, Ziauddin 2018. ERG6 and ERG2 are major targets conferring reduced susceptibility to amphotericin B in clinical Candida glabrata isolates in Kuwait. Antimicrobial Agents and Chemotherapy 63 (2) , e01900-18. 10.1128/AAC.01900-18

Zhou, Wenxu, Warrilow, Andrew G.S., Thomas, Crista D., Ramos, Emilio, Parker, Josie E., Price, Claire L., Vanderloop, Boden H., Fisher, Paxtyn M., Loftis, Michael D., Kelly, Diane E., Kelly, Steven L. and Nes, W. David 2018. Functional importance for developmental regulation of sterol biosynthesis in Acanthamoeba castellanii. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1863 (10) , pp. 1164-1178. 10.1016/j.bbalip.2018.07.004

Luna-Tapia, Arturo, Willems, Hubertine M. E., Parker, Josie E., Tournu, Hélène, Barker, Katherine S., Nishimoto, Andrew T., Rogers, P. David, Kelly, Steven L., Peters, Brian M., Palmer, Glen E. and Alspaugh, J. Andrew 2018. Loss of Upc2p-inducible Erg3 transcription is sufficient to confer niche-specific azole resistance without compromising Candida albicans pathogenicity. mBio 9 (3) , e00225-18. 10.1128/mBio.00225-18
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Colley, Thomas, Sehra, Gurpreet, Chowdhary, Anuradha, Alanio, Alexandre, Kelly, Steven L., Kizawa, Yasuo, Armstrong-James, Darius, Fisher, Matthew C., Warrilow, Andrew G. S., Parker, Josie E., Kelly, Diane E., Kimura, Genki, Nishimoto, Yuki, Sunose, Mihiro, Onions, Stuart, Crepin, Damien, Lagasse, Franz, Crittall, Matthew, Shannon, Jonathan, McConville, Matthew, King-Underwood, John, Naylor, Alan, Bretagne, Stéphane, Murray, John, Ito, Kazuhiro, Strong, Pete and Rapeport, Garth 2018. In vitro and in vivo efficacy of a novel and long-acting fungicidal azole, PC1244, on Aspergillus fumigatus infection. Antimicrobial Agents and Chemotherapy 62 (5) , e01941-17. 10.1128/AAC.01941-17
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Butts, Arielle, DeJarnette, Christian, Peters, Tracy L., Parker, Josie E., Kerns, Morgan E., Eberle, Karen E., Kelly, Steve L., Palmer, Glen E. and Alspaugh, J. Andrew 2017. Target abundance-based fitness screening (TAFiS) facilitates rapid identification of target-specific and physiologically active chemical probes. mSphere 2 (5) , e00379-17. 10.1128/mSphere.00379-17
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Rybak, Jeffrey M., Dickens, C. Michael, Parker, Josie E., Caudle, Kelly E., Manigaba, Kayihura, Whaley, Sarah G., Nishimoto, Andrew T., Luna-Tapia, Arturo, Roy, Sujoy, Zhang, Qing, Barker, Katherine S., Palmer, Glen E., Sutter, Thomas R., Homayouni, Ramin, Wiederhold, Nathan P., Kelly, Steven L. and Rogers, P. David 2017. Loss of C-5 sterol desaturase activity results in increased resistance to azole and echinocandin antifungals in a clinical isolate of Candida parapsilosis. Antimicrobial Agents and Chemotherapy 61 (9) , e00651-17. 10.1128/AAC.00651-17

Colley, Thomas, Alanio, Alexandre, Kelly, Steven L., Sehra, Gurpreet, Kizawa, Yasuo, Warrilow, Andrew G. S., Parker, Josie E., Kelly, Diane E., Kimura, Genki, Anderson-Dring, Lauren, Nakaoki, Takahiro, Sunose, Mihiro, Onions, Stuart, Crepin, Damien, Lagasse, Franz, Crittall, Matthew, Shannon, Jonathan, Cooke, Michael, Bretagne, Stéphane, King-Underwood, John, Murray, John, Ito, Kazuhiro, Strong, Pete and Rapeport, Garth 2017. In vitro and in vivo antifungal profile of a novel and long-acting inhaled azole, PC945, on Aspergillus fumigatus infection. Antimicrobial Agents and Chemotherapy 61 (5) , e02280-16. 10.1128/AAC.02280-16
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McCourt, Paula, Liu, Hsing-Yin, Parker, Josie E., Gallo-Ebert, Christina, Donigan, Melissa, Bata, Adam, Giordano, Caroline, Kelly, Steven L. and Nickels, Joseph T. 2016. Proper sterol distribution is required for Candida albicans hyphal formation and virulence. G3: Genes | Genomes | Genetics 6 (11) , pp. 3455-3465. 10.1534/g3.116.033969
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Warrilow, Andrew G. S., Parker, Josie E., Price, Claire L., Nes, W. David, Garvey, Edward P., Hoekstra, William J., Schotzinger, Robert J., Kelly, Diane E. and Kelly, Steven L. 2016. The investigational drug VT-1129 is a highly potent inhibitor of Cryptococcus species CYP51 but only weakly inhibits the human enzyme. Antimicrobial Agents and Chemotherapy 60 (8) , pp. 4530-4538. 10.1128/AAC.00349-16

Warrilow, Andrew G. S., Price, Claire L., Parker, Josie E., Rolley, Nicola J., Smyrniotis, Christopher J., Hughes, David D., Thoss, Vera, Nes, W. David, Kelly, Diane E., Holman, Theodore R. and Kelly, Steven L. 2016. Azole antifungal sensitivity of sterol 14α-demethylase (cyp51) and cyp5218 from Malassezia globosa. Scientific Reports 6 (1) , 27690. 10.1038/srep27690
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This list was generated on Mon Dec 30 05:08:20 2024 GMT.


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