Titration of C-5 Sterol Desaturase Activity Reveals Its Relationship to Candida albicans Virulence and Antifungal Susceptibility Is Dependent upon Host Immune Status

Regan, Jessica, DeJarnette, Christian, Luna-Tapia, Arturo, Parker, Josie E., Reitler, Parker, Barnett, Stacey, Tucker, Katie M., Kelly, Steven L and Palmer, Glen E 2022. Titration of C-5 Sterol Desaturase Activity Reveals Its Relationship to Candida albicans Virulence and Antifungal Susceptibility Is Dependent upon Host Immune Status. mBio 13 (2) 10.1128/mbio.00115-22

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Abstract

Mutations that completely inactivate Erg3p enable the prevalent human pathogen C. albicans to endure the azole antifungals in vitro . However, such null mutants are less frequently identified in azole-resistant clinical isolates than other resistance mechanisms, and previous studies have reported conflicting outcomes regarding antifungal resistance of these mutants in animal models of infection.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences
Publisher:	American Society for Microbiology
ISSN:	2150-7511
Date of First Compliant Deposit:	12 October 2022
Date of Acceptance:	7 March 2022
Last Modified:	11 May 2023 13:11
URI:	https://orca.cardiff.ac.uk/id/eprint/153113

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