Cardella, Davide, Tsai, Yu-Hsuan  ORCID: https://orcid.org/0000-0003-0589-5088 and Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261
2023.
Towards the use of an amino acid cleavable linker for solid-phase chemical synthesis of peptides and proteins.
Organic and Biomolecular Chemistry
21
, pp. 966-969.
10.1039/d2ob02198f
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License URL: http://creativecommons.org/licenses/by/3.0/
License Start date: 23 December 2022
Official URL: https://doi.org/10.1039/d2ob02198f
Abstract
The synthesis of proteins by solid-phase chemical ligation (SPCL) suffers from the paucity of linkers that can be cleaved under mild conditions. Here, we deployed a spontaneous nickel-assisted cleavage (SNAC) tag, known to undergo spontaneous cleavage in the presence of nickel(ii), as a linker for C-to-N SPCL.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Chemistry |
| Additional Information: | License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/3.0/, Start Date: 2022-12-23 |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1477-0520 |
| Date of First Compliant Deposit: | 12 January 2023 |
| Date of Acceptance: | 22 December 2022 |
| Last Modified: | 05 May 2023 14:30 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/155805 |
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