Cardella, Davide, Tsai, Yu-Hsuan ![]() ![]() ![]() |
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License URL: http://creativecommons.org/licenses/by/3.0/
License Start date: 23 December 2022
Official URL: https://doi.org/10.1039/d2ob02198f
Abstract
The synthesis of proteins by solid-phase chemical ligation (SPCL) suffers from the paucity of linkers that can be cleaved under mild conditions. Here, we deployed a spontaneous nickel-assisted cleavage (SNAC) tag, known to undergo spontaneous cleavage in the presence of nickel(ii), as a linker for C-to-N SPCL.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry |
Additional Information: | License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/3.0/, Start Date: 2022-12-23 |
Publisher: | Royal Society of Chemistry |
ISSN: | 1477-0520 |
Date of First Compliant Deposit: | 12 January 2023 |
Date of Acceptance: | 22 December 2022 |
Last Modified: | 05 May 2023 14:30 |
URI: | https://orca.cardiff.ac.uk/id/eprint/155805 |
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