Hardwicke, Joseph., Song, Bing ![]() ![]() ![]() |
Abstract
In this study, the first use of a bioresponsive polymer therapeutic agent in the promotion of corneal re-epithelialisation after injury in an ex vivo whole-eye organ culture model was described. A polymer–protein conjugate consisting of dextrin and recombinant human epidermal growth factor was synthesised and applied as a single dose to a 2 mm ex vivo corneal ulcer, in culture. Enhanced wound healing was observed in response to dextrin–recombinant human epidermal growth factor, when exposed to α-amylase, compared with controls. This highlights the potential for polymer therapeutics to provide a platform for bioresponsive drug/protein delivery in the field of ophthalmology.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Dentistry Systems Immunity Research Institute (SIURI) |
Subjects: | R Medicine > RE Ophthalmology |
Publisher: | BMJ Publishing Group |
ISSN: | 0007-1161 |
Last Modified: | 18 Oct 2022 13:55 |
URI: | https://orca.cardiff.ac.uk/id/eprint/15881 |
Citation Data
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