Investigation of the potential of polymer therapeutics in corneal re-epithelialisation

Hardwicke, Joseph., Song, Bing ORCID: https://orcid.org/0000-0001-9356-2333, Moseley, Ryan ORCID: https://orcid.org/0000-0002-2812-6735 and Thomas, David William ORCID: https://orcid.org/0000-0001-7319-5820 2010. Investigation of the potential of polymer therapeutics in corneal re-epithelialisation. British Journal of Ophthalmology 94 (12) , pp. 1566-1570. 10.1136/bjo.2009.177295

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Abstract

In this study, the first use of a bioresponsive polymer therapeutic agent in the promotion of corneal re-epithelialisation after injury in an ex vivo whole-eye organ culture model was described. A polymer–protein conjugate consisting of dextrin and recombinant human epidermal growth factor was synthesised and applied as a single dose to a 2 mm ex vivo corneal ulcer, in culture. Enhanced wound healing was observed in response to dextrin–recombinant human epidermal growth factor, when exposed to α-amylase, compared with controls. This highlights the potential for polymer therapeutics to provide a platform for bioresponsive drug/protein delivery in the field of ophthalmology.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > RE Ophthalmology
Publisher:	BMJ Publishing Group
ISSN:	0007-1161
Last Modified:	18 Oct 2022 13:55
URI:	https://orca.cardiff.ac.uk/id/eprint/15881

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