Antimicrobial tolerance and the significance of persister cells in recalcitrant chronic wound biofilms

Percival, S. L., Hill, Katja E. ORCID: https://orcid.org/0000-0002-8590-0117, Malic, Sladjana, Thomas, David William ORCID: https://orcid.org/0000-0001-7319-5820 and Williams, David Wynne ORCID: https://orcid.org/0000-0002-7351-5131 2011. Antimicrobial tolerance and the significance of persister cells in recalcitrant chronic wound biofilms. Wound Repair and Regeneration 19 (1) , pp. 1-9. 10.1111/j.1524-475X.2010.00651.x

Full text not available from this repository.

Abstract

The application of antimicrobials in the management of wounds is a complex procedure requiring appropriate clinical decision making, judgment and a thorough understanding of antimicrobial therapies, together with their potential disadvantages. There is considerable direct and indirect evidence for the presence of bacterial biofilms in the chronic wound bed, and it has been demonstrated that bacteria within these biofilms may exhibit both specific and nonspecific antimicrobial tolerance. The antimicrobial tolerance of biofilms is a major concern in the treatment of both infected and nonhealing chronic wounds and an understanding of the mechanisms involved is of fundamental importance in managing wound infections and developing future wound management strategies. The aim of this review is therefore to provide an overview of our current understanding of the mechanisms by which bacteria in wound biofilms can resist conventional antibiotic and antibacterial therapies which is very important to wound healing. © 2011 by the Wound Healing Society.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry Systems Immunity Research Institute (SIURI)
Publisher:	Wiley
ISSN:	1067-1927
Last Modified:	18 Oct 2022 13:57
URI:	https://orca.cardiff.ac.uk/id/eprint/16015

Citation Data

Cited 138 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item