The link between T cell activation and development of functionally useful tumour-associated high endothelial venules

Milutinovic, Stefan ORCID: https://orcid.org/0000-0002-3163-3383 and Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004 2023. The link between T cell activation and development of functionally useful tumour-associated high endothelial venules. Discovery Immunology 2 (1) , kyad006. 10.1093/discim/kyad006

PDF - Published Version Available under License Creative Commons Attribution. Download (666kB)

Abstract

High endothelial venules (HEVs) are specialized postcapillary venules that specifically serve to recruit circulating lymphocytes to secondary lymphoid organs (SLOs) where cognate antigens can be encountered, and immune responses can be initiated. The presence of HEV-like vessels in primary human solid tumours and their association with lymphocyte infiltration and favourable clinical outcomes and response to immunotherapy have provided a rationale for therapeutically inducing these vessels in tumours for immunotherapeutic benefit. Here we specifically discuss evidence for a link between T-cell activation and development of useful tumour-associated HEV (TA-HEV). We discuss the molecular and functional features of TA-HEV, highlighting the benefits for promoting tumour immunity and the important unanswered questions that need to be addressed before TA-HEV induction can be optimized for immunotherapeutic benefit.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Oxford University Press
ISSN:	2754-2483
Date of First Compliant Deposit:	6 June 2023
Date of Acceptance:	24 April 2023
Last Modified:	02 Aug 2023 16:48
URI:	https://orca.cardiff.ac.uk/id/eprint/160188

Actions (repository staff only)

Edit Item