Transcriptional control of embryonic and adult neural progenitor activity

Singh, Niharika, Siebzehnrubl, Florian A. ORCID: https://orcid.org/0000-0001-8411-8775 and Martinez Garay, Isabel ORCID: https://orcid.org/0000-0001-6849-7496 2023. Transcriptional control of embryonic and adult neural progenitor activity. Frontiers in Neuroscience 17 , 1217596. 10.3389/fnins.2023.1217596

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Abstract

Neural precursors generate neurons in the embryonic brain and in restricted niches of the adult brain in a process called neurogenesis. The precise control of cell proliferation and differentiation in time and space required for neurogenesis depends on sophisticated orchestration of gene transcription in neural precursor cells. Much progress has been made in understanding the transcriptional regulation of neurogenesis, which relies on dose- and context-dependent expression of specific transcription factors that regulate the maintenance and proliferation of neural progenitors, followed by their differentiation into lineage-specified cells. Here, we review some of the most widely studied neurogenic transcription factors in the embryonic cortex and neurogenic niches in the adult brain. We compare functions of these transcription factors in embryonic and adult neurogenesis, highlighting biochemical, developmental, and cell biological properties. Our goal is to present an overview of transcriptional regulation underlying neurogenesis in the developing cerebral cortex and in the adult brain.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences European Cancer Stem Cell Research Institute (ECSCRI)
Publisher:	Frontiers
ISSN:	1662-4548
Funders:	BBSRC, MRC
Date of First Compliant Deposit:	17 July 2023
Date of Acceptance:	10 July 2023
Last Modified:	21 Sep 2023 17:05
URI:	https://orca.cardiff.ac.uk/id/eprint/161069

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