Emerging SARS-CoV-2 variants: Why, how, and what's next?

Chen, Yu, Liu, Qianyun, Zhou, Li, Zhou, You ORCID: https://orcid.org/0000-0002-1743-1291, Yan, Huan and Lan, Ke 2023. Emerging SARS-CoV-2 variants: Why, how, and what's next? Cell Insight 1 (3) , 100029. 10.1016/j.cellin.2022.100029

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Abstract

The emergence of the SARS-CoV-2 Omicron variant poses a striking threat to human society. More than 30 mutations in the Spike protein of the Omicron variant severely compromised the protective immunity elicited by either vaccination or prior infection. The persistent viral evolutionary trajectory generates Omicron-associated lineages, such as BA.1 and BA.2. Moreover, the virus recombination upon Delta and Omicron co-infections has been reported lately, although the impact remains to be assessed. This minireview summarizes the characteristics, evolution and mutation control, and immune evasion mechanisms of SARS-CoV-2 variants, which will be helpful for the in-depth understanding of the SARS-CoV-2 variants and policy-making related to COVID-19 pandemic control.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
ISSN:	2772-8927
Date of First Compliant Deposit:	19 July 2023
Date of Acceptance:	27 April 2023
Last Modified:	21 Jul 2023 07:49
URI:	https://orca.cardiff.ac.uk/id/eprint/161121

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