Macrolides and community-acquired pneumonia: is quorum sensing the key?

Wise, Matthew Peter, Williams, David Wynne ORCID: https://orcid.org/0000-0002-7351-5131, Lewis, Michael Alexander Oxenham ORCID: https://orcid.org/0000-0003-1917-0651 and Frost, Paul John 2010. Macrolides and community-acquired pneumonia: is quorum sensing the key? Critical care (London, England) 14 (4) , 181. 10.1186/cc9084

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Abstract

Combination therapy with two antimicrobial agents is superior to monotherapy in severe community-acquired pneumonia, and recent data suggest that addition of a macrolide as the second antibiotic might be superior to other combinations. This observation requires confirmation in a randomised control trial, but this group of antibiotics have pleiotropic effects that extend beyond bacterial killing. Macrolides inhibit bacterial cell-to-cell communication or quorum sensing, which not only might be an important mechanism of action for these drugs in severe infections but may also provide a novel target for the development of new anti-infective drugs

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Dentistry Schools > Medicine
Publisher:	BioMed Central Ltd
ISSN:	1364-8535
Date of First Compliant Deposit:	30 March 2016
Last Modified:	05 Oct 2023 15:16
URI:	https://orca.cardiff.ac.uk/id/eprint/16120

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