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Macrolides and community-acquired pneumonia: is quorum sensing the key?

Wise, Matthew Peter, Williams, David Wynne ORCID:, Lewis, Michael Alexander Oxenham ORCID: and Frost, Paul John 2010. Macrolides and community-acquired pneumonia: is quorum sensing the key? Critical care (London, England) 14 (4) , 181. 10.1186/cc9084

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Combination therapy with two antimicrobial agents is superior to monotherapy in severe community-acquired pneumonia, and recent data suggest that addition of a macrolide as the second antibiotic might be superior to other combinations. This observation requires confirmation in a randomised control trial, but this group of antibiotics have pleiotropic effects that extend beyond bacterial killing. Macrolides inhibit bacterial cell-to-cell communication or quorum sensing, which not only might be an important mechanism of action for these drugs in severe infections but may also provide a novel target for the development of new anti-infective drugs

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Publisher: BioMed Central Ltd
ISSN: 1364-8535
Date of First Compliant Deposit: 30 March 2016
Last Modified: 18 Aug 2023 09:48

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