Wise, Matthew Peter, Williams, David Wynne ![]() ![]() |
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Abstract
Combination therapy with two antimicrobial agents is superior to monotherapy in severe community-acquired pneumonia, and recent data suggest that addition of a macrolide as the second antibiotic might be superior to other combinations. This observation requires confirmation in a randomised control trial, but this group of antibiotics have pleiotropic effects that extend beyond bacterial killing. Macrolides inhibit bacterial cell-to-cell communication or quorum sensing, which not only might be an important mechanism of action for these drugs in severe infections but may also provide a novel target for the development of new anti-infective drugs
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Dentistry Medicine |
Publisher: | BioMed Central Ltd |
ISSN: | 1364-8535 |
Date of First Compliant Deposit: | 30 March 2016 |
Last Modified: | 21 May 2023 17:01 |
URI: | https://orca.cardiff.ac.uk/id/eprint/16120 |
Citation Data
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