Inactivation of human plasma C1-inhibitor by human PMN leucocyte matrix metalloproteinases

Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Triebel, Susanne, Reinke, Heinz and Tschesche, Harald 1991. Inactivation of human plasma C1-inhibitor by human PMN leucocyte matrix metalloproteinases. FEBS Letters 290 (1-2) , pp. 99-102. 10.1016/0014-5793(91)81235-Z

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Abstract

Highly purified human polymorphonuclear (PMN) leucocyte matrix metalloproteinases, collagenase and gelatinase, cleaved human plasma C1-inhibitor at the carboxyl site of Ala439 (P6). This led to a concomitant loss of C1-inhibitor activity. An additional cleavage site at the carboxyl site of Ser441 (P4), was observed during PMN leucocyte gelatinase-induced inactivation, and a minor fragment of the plasma C1-inhibitor was generated.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry
Publisher:	Federation of European Biochemical Societies
ISSN:	1873-3468
Last Modified:	31 Aug 2023 15:16
URI:	https://orca.cardiff.ac.uk/id/eprint/161613

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