Bispecific antibodies in hematological malignancies: a scoping review

Omer, Mohamed ORCID: https://orcid.org/0000-0001-5967-9984, Shafqat, Areez, Ahmad, Omar, Alkattan, Khaled, Yaqinuddin, Ahmed and Damlaj, Moussab 2023. Bispecific antibodies in hematological malignancies: a scoping review. Cancers 15 (18) , 4550. 10.3390/cancers15184550

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Abstract

Bispecific T-cell engagers (BiTEs) and bispecific antibodies (BiAbs) have revolutionized the treatment landscape of hematological malignancies. By directing T cells towards specific tumor antigens, BiTEs and BiAbs facilitate the T-cell-mediated lysis of neoplastic cells. The success of blinatumomab, a CD19xCD3 BiTE, in acute lymphoblastic leukemia spearheaded the expansive development of BiTEs/BiAbs in the context of hematological neoplasms. Nearly a decade later, numerous BiTEs/BiAbs targeting a range of tumor-associated antigens have transpired in the treatment of multiple myeloma, non-Hodgkin’s lymphoma, acute myelogenous leukemia, and acute lymphoblastic leukemia. However, despite their generally favorable safety profiles, particular toxicities such as infections, cytokine release syndrome, myelosuppression, and neurotoxicity after BiAb/BiTE therapy raise valid concerns. Moreover, target antigen loss and the immunosuppressive microenvironment of hematological neoplasms facilitate resistance towards BiTEs/BiAbs. This review aims to highlight the most recent evidence from clinical trials evaluating the safety and efficacy of BiAbs/BiTEs. Additionally, the review will provide mechanistic insights into the limitations of BiAbs whilst outlining practical applications and strategies to overcome these limitations.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	MDPI
ISSN:	2072-6694
Date of First Compliant Deposit:	5 October 2023
Date of Acceptance:	28 August 2023
Last Modified:	06 Oct 2023 05:06
URI:	https://orca.cardiff.ac.uk/id/eprint/162935

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