Challenges and perspectives for naming lipids in the context of lipidomics

Witting, Michael, Malik, Adnan, Leach, Andrew, Bridge, Alan, Aimo, Lucila, Conroy, Matthew J., O’Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460, Hoffmann, Nils, Kopczynski, Dominik, Giacomoni, Franck, Paulhe, Nils, Gassiot, Amaury Cazenave, Poupin, Nathalie, Jourdan, Fabien and Bertrand-Michel, Justine 2024. Challenges and perspectives for naming lipids in the context of lipidomics. Metabolomics 20 (1) , 15. 10.1007/s11306-023-02075-x

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Abstract

Introduction: Lipids are key compounds in the study of metabolism and are increasingly studied in biology projects. It is a very broad family that encompasses many compounds, and the name of the same compound may vary depending on the community where they are studied. Objectives: In addition, their structures are varied and complex, which complicates their analysis. Indeed, the structural resolution does not always allow a complete level of annotation so the actual compound analysed will vary from study to study and should be clearly stated. For all these reasons the identification and naming of lipids is complicated and very variable from one study to another, it needs to be harmonized. Methods & Results: In this position paper we will present and discuss the different way to name lipids (with chemoinformatic and semantic identifiers) and their importance to share lipidomic results. Conclusion: Homogenising this identification and adopting the same rules is essential to be able to share data within the community and to map data on functional networks.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/4.0/, Type: open-access
Publisher:	Springer
ISSN:	1573-3882
Date of First Compliant Deposit:	26 January 2024
Date of Acceptance:	1 December 2023
Last Modified:	26 Jan 2024 09:15
URI:	https://orca.cardiff.ac.uk/id/eprint/165831

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