Hyaluronan in kidney fibrosis

Grigorieva, Irina, Woods, Emma L., Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496, Bowen, Timothy ORCID: https://orcid.org/0000-0001-6050-0435 and Meran, Soma ORCID: https://orcid.org/0000-0003-3408-3978 2023. Hyaluronan in kidney fibrosis. Passi, Alberto, ed. Hyaluronan: Structure, Biology and Biotechnology, Vol. 14. Biology of Extracellular Matrix, Springer, pp. 77-97. (10.1007/978-3-031-30300-5_5)

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Abstract

The kidney is the organ responsible for the regulation of the body’s fluid balance. Hyaluronan (HA), because of its unique hydration capacity, is used dynamically by the normal renal medulla to ensure whole-body fluid homeostasis. While levels of HA in the medulla fluctuate and can be very high, HA levels in the renal cortex remain static and are almost undetectable. Levels in the cortex are only upregulated in both acute and chronic renal diseases such as diabetes, ischemia-reperfusion injury, tubulointerstitial inflammation and renal transplant rejection. This chapter describes our current understanding of the mechanisms controlling the upregulation of HA in progressive disease, their potential recapitulation of embryonic events and which intracellular signalling pathways may have the potential to prevent or reverse the progression that leads to End Stage Renal Failure.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Springer
ISBN:	9783031302992
ISSN:	0887-3224
Last Modified:	21 Feb 2024 11:00
URI:	https://orca.cardiff.ac.uk/id/eprint/166355

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