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Hamilton, Karina D., Czajkowski, Daniel, Kong, Nicolas J., Tran, Trong D., Gustafson, Kirk R., Pauly, Gary, Boyle, Glen M., Simmons, Jacinta L., Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496, Moseley, Ryan ORCID: https://orcid.org/0000-0002-2812-6735, Brooks, Peter R., Ogbourne, Steven M. and Russell, Fraser D. 2022. Anti-fibrotic potential of Tomentosenol A, a constituent of cerumen from the Australian native stingless bee, Tetragonula carbonaria. Antioxidants 11 (8) , e1604. 10.3390/antiox11081604 |
Woods, Emma L., Grigorieva, Irina V., Midgley, Adam C., Brown, Charlotte V.M., Lu, Yueh-an, Phillips, Aled O. ORCID: https://orcid.org/0000-0001-9744-7113, Bowen, Timothy ORCID: https://orcid.org/0000-0001-6050-0435, Meran, Soma ORCID: https://orcid.org/0000-0003-3408-3978 and Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 2021. CD147 mediates the CD44s-dependent differentiation of myofibroblasts driven by transforming growth factor-β1. Journal of Biological Chemistry 297 (3) , 100987. 10.1016/j.jbc.2021.100987 |
Tai, Yifan, Woods, Emma L., Dally, Jordanna, Kong, Deling, Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496, Moseley, Ryan ORCID: https://orcid.org/0000-0002-2812-6735 and Midgley, Adam C. 2021. Myofibroblasts: function, formation, and scope of molecular therapies for skin fibrosis. Biomolecules 11 (8) , 1095. 10.3390/biom11081095 |
Moses, Rachael L., Boyle, Glen M., Howard-Jones, Rachel A. ORCID: https://orcid.org/0000-0001-7200-3110, Errington, Rachel J. ORCID: https://orcid.org/0000-0002-8016-4376, Johns, Jenny P., Gordon, Victoria, Reddell, Paul, Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 and Moseley, Ryan ORCID: https://orcid.org/0000-0002-2812-6735 2020. Novel epoxy-tiglianes stimulate skin keratinocyte wound healing responses and re-epithelialization via protein kinase C activation. Biochemical Pharmacology 178 , 114048. 10.1016/j.bcp.2020.114048 |
Midgley, Adam C., Woods, Emma, Jenkins, Robert ORCID: https://orcid.org/0000-0001-8500-9044, Brown, Charlotte, Khalid, Usman, Chavez, Rafael, Hascall, Vincent, Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496, Phillips, Aled O. ORCID: https://orcid.org/0000-0001-9744-7113 and Meran, Soma ORCID: https://orcid.org/0000-0003-3408-3978 2020. Hyaluronidase-2 regulates RhoA signalling, myofibroblast contractility and other key pro-fibrotic myofibroblast functions. American Journal of Pathology 190 (6) , pp. 1236-1255. 10.1016/j.ajpath.2020.02.012 |
Wilson, Nicholas, Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496, Muller, Ilaria ORCID: https://orcid.org/0000-0003-2926-0722, Draman, Mohd, Rees, D. Aled ORCID: https://orcid.org/0000-0002-1165-9092, Taylor, Peter ORCID: https://orcid.org/0000-0002-3436-422X, Dayan, Colin M. ORCID: https://orcid.org/0000-0002-6557-3462, Ludgate, Marian and Zhang, Lei ORCID: https://orcid.org/0000-0003-3536-8692 2019. Role of hyaluronan in human adipogenesis: Evidence from in-vitro and in-vivo studies. International Journal of Molecular Sciences 20 (11) , 2675. 10.3390/ijms20112675 |
Midgley, Adam C., Oltean, Sebastian, Hascall, Vincent, Woods, Emma L., Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496, Phillips, Aled O. ORCID: https://orcid.org/0000-0001-9744-7113 and Meran, Soma ORCID: https://orcid.org/0000-0003-3408-3978 2017. Nuclear hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA to determine profibrotic or antifibrotic cell phenotype. Science Signaling 10 (506) , eaao1822. 10.1126/scisignal.aao1822 |
Dally, Jordanna, Khan, Jabur S., Voisey, Alex ORCID: https://orcid.org/0000-0001-6906-9397, Charalambous, Chrisandrea, John, Hannah L., Woods, Emma L., Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496, Moseley, Ryan ORCID: https://orcid.org/0000-0002-2812-6735 and Midgley, Adam C. 2017. Hepatocyte growth factor mediates enhanced wound healing responses and resistance to transforming growth factor-β1-driven myofibroblast differentiation in oral mucosal fibroblasts. International Journal of Molecular Sciences 18 , 1843. 10.3390/ijms18091843 |
Midgley, Adam C., Morris, Glyn, Phillips, Aled O. ORCID: https://orcid.org/0000-0001-9744-7113 and Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 2016. 17β‐estradiol ameliorates age‐associated loss of fibroblast function by attenuating IFN‐γ/STAT1‐dependent miR‐7 upregulation. Aging Cell 15 (3) , pp. 531-541. 10.1111/acel.12462 |
Martin, John, Midgley, Adam, Meran, Soma ORCID: https://orcid.org/0000-0003-3408-3978, Woods, Emma, Bowen, Timothy ORCID: https://orcid.org/0000-0001-6050-0435, Phillips, Aled O. ORCID: https://orcid.org/0000-0001-9744-7113 and Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 2016. Tumour necrosis factor-stimulated gene (TSG)-6-mediated interactions with the inter-alpha-inhibitor heavy chain 5 facilitate TGF beta1-dependent fibroblast to myofibroblast differentiation. Journal of Biological Chemistry 291 , pp. 13789-13801. 10.1074/jbc.M115.670521 |
Midgley, Adam C., Druggal, Lucy, Jenkins, Robert ORCID: https://orcid.org/0000-0001-8500-9044, Hascall, Vincent, Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496, Phillips, Aled O. ORCID: https://orcid.org/0000-0001-9744-7113 and Meran, Soma ORCID: https://orcid.org/0000-0003-3408-3978 2015. Hyaluronan regulates bone morphogenetic protein-7-dependent prevention and reversal of myofibroblast phenotype. Journal of Biological Chemistry 290 (18) , pp. 11218-11234. 10.1074/jbc.M114.625939 |
Meran, Soma ORCID: https://orcid.org/0000-0003-3408-3978, Martin, John, Luo, Dong Dong, Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 and Phillips, Aled Owain ORCID: https://orcid.org/0000-0001-9744-7113 2013. Interleukin-1β induces hyaluronan and CD44-dependent cell protrusions that facilitate fibroblast-monocyte binding. American Journal of Pathology 182 (6) , pp. 2223-2240. 10.1016/j.ajpath.2013.02.038 |
Bommayya, Girish, Meran, Soma ORCID: https://orcid.org/0000-0003-3408-3978, Krupa, Aleksandra, Phillips, Aled Owain ORCID: https://orcid.org/0000-0001-9744-7113 and Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 2011. Tumour necrosis factor-stimulated gene (TSG)-6 controls epithelial–mesenchymal transition of proximal tubular epithelial cells. International Journal of Biochemistry & Cell Biology 43 (12) , pp. 1739-1746. 10.1016/j.biocel.2011.08.009 |
Meran, Soma ORCID: https://orcid.org/0000-0003-3408-3978, Luo, Dong Dong, Simpson, Russell M. L., Martin, John, Wells, Alan, Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 and Phillips, Aled Owain ORCID: https://orcid.org/0000-0001-9744-7113 2011. Hyaluronan facilitates transforming growth factor-β1-dependent proliferation via CD44 and epidermal growth factor receptor interaction. Journal of Biological Chemistry 286 (20) , pp. 17618-17630. 10.1074/jbc.M111.226563 |
Meran, Soma ORCID: https://orcid.org/0000-0003-3408-3978 and Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 2011. Fibroblasts and myofibroblasts in renal fibrosis. International Journal of Experimental Pathology 92 (3) , pp. 158-167. 10.1111/j.1365-2613.2011.00764.x |
Khammas, Hassan, Bowen, Timothy ORCID: https://orcid.org/0000-0001-6050-0435, Williams, John David, Phillips, Aled Owain ORCID: https://orcid.org/0000-0001-9744-7113, Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 and Martin, John 2011. Characterisation of the human ADAM15 promoter. Nephron Experimental Nephrology 118 (2) , e27-e38. 10.1159/000320698 |
Simpson, Russell M. L., Wells, Alan, Thomas, David William ORCID: https://orcid.org/0000-0001-7319-5820, Stephens, Philip ORCID: https://orcid.org/0000-0002-0840-4996, Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 and Phillips, Aled Owain ORCID: https://orcid.org/0000-0001-9744-7113 2010. Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling. American Journal of Pathology 176 (3) , pp. 1215-1228. 10.2353/ajpath.2010.090802 |
Zhang, Lei ORCID: https://orcid.org/0000-0003-3536-8692, Bowen, Timothy ORCID: https://orcid.org/0000-0001-6050-0435, Grennan-Jones, Fiona Antoinette, Paddon, Carol Ann, Giles, Peter James ORCID: https://orcid.org/0000-0003-3143-6854, Webber, Jason P. ORCID: https://orcid.org/0000-0003-4772-3014, Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 and Ludgate, Marian Elizabeth 2009. Thyrotropin receptor activation increases hyaluronan production in preadipocyte fibroblasts: Contributory role in hyaluronan accumulation in thyroid dysfunction. Journal of Biological Chemistry 284 (39) , pp. 26447-26455. 10.1074/jbc.M109.003616 |
Simpson, Russell M.L., Stephens, Philip ORCID: https://orcid.org/0000-0002-0840-4996, Thomas, David ORCID: https://orcid.org/0000-0001-7319-5820, Webber, J. P., Meran, Soma ORCID: https://orcid.org/0000-0003-3408-3978, Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 and Phillips, Aled Owain ORCID: https://orcid.org/0000-0001-9744-7113 2009. Age related changes in pericellular hyaluronan leads to impaired dermal fibroblast to myofibroblast differentiation. International Journal of Experimental Pathology 90 (2) , A128-A129. |
Meran, Soma ORCID: https://orcid.org/0000-0003-3408-3978, Thomas, David William ORCID: https://orcid.org/0000-0001-7319-5820, Stephens, Philip ORCID: https://orcid.org/0000-0002-0840-4996, Enoch, Stuart, Martin, John, Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 and Phillips, Aled Owain ORCID: https://orcid.org/0000-0001-9744-7113 2008. Hyaluronan facilitates transforming growth factor-β1-mediated fibroblast proliferation. Journal of Biological Chemistry 283 (10) , pp. 6530-6545. 10.1074/jbc.M704819200 |
Lewis, Aled G., Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496, Manley, Paul, Craig, Kathrine Jane, de la Motte, Carol, Hascall, Vincent and Phillips, Aled Owain ORCID: https://orcid.org/0000-0001-9744-7113 2008. Diabetic nephropathy, inflammation, hyaluronan and interstitial fibrosis. Histology and Histopathology 23 (6) , pp. 731-739. |
Kastner, Sabine, Thomas, Gareth John, Jenkins, Robert Hywel ORCID: https://orcid.org/0000-0001-8500-9044, Davies, Malcolm and Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 2007. Hyaluronan induces the selective accumulation of matrix- and cell-associated proteoglycans by mesangial cells. American Journal of Pathology 171 , pp. 1811-1821. 10.2353/ajpath.2007.070085 |
Martin, John, Bowen, Timothy ORCID: https://orcid.org/0000-0001-6050-0435 and Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 2006. The pluripotent cytokine pleiotrophin is induced by wounding in human mesangial cells. Kidney International 70 (9) , pp. 1616-1622. 10.1038/sj.ki.5001800 |
Khera, Tarnjit, Martin, John, Riley, Stephen George, Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 and Phillips, Aled Owain ORCID: https://orcid.org/0000-0001-9744-7113 2006. Glucose enhances mesangial cell apoptosis. Laboratory Investigation 86 (6) , pp. 566-577. 10.1038/labinvest.3700418 |
Jenkins, Robert Hywel ORCID: https://orcid.org/0000-0001-8500-9044, Thomas, Gareth John, Williams, John David and Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 2004. Myofibroblastic differentiation leads to hyaluronan accumulation through reduced hyaluronan turnover. The Journal of Biological Chemistry 279 (40) , pp. 41453-41460. 10.1074/jbc.M401678200 |
Thomas, Gareth John, Clayton, Aled ORCID: https://orcid.org/0000-0002-3087-9226, Thomas, Janet, Davies, Malcolm and Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 2003. Structural and functional changes in heparan sulfate proteoglycan expression associated with the myofibroblastic phenotype. America Journal of Pathology 162 (3) , pp. 977-989. |
Blaber, Robert, Stylianou, Eleni, Clayton, Aled ORCID: https://orcid.org/0000-0002-3087-9226 and Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 2003. Selective regulation of ICAM-1 and RANTES gene expression after ICAM-1 ligation on human renal fibroblasts. Journal of the American Society of Nephrology 14 (1) , pp. 116-127. 10.1097/01.ASN.0000040595.35207.62 |
Martin, John, Eynstone, Lisa V., Davies, Malcolm, Williams, John David and Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 2002. The role of ADAM 15 in glomerular mesangial cell migration. The Journal of Biological Chemistry 277 (37) , pp. 33683-33689. 10.1074/jbc.M200988200 |
Clayton, Aled ORCID: https://orcid.org/0000-0002-3087-9226, Thomas, Janet, Thomas, Gareth J., Davies, Malcolm and Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 2001. Cell surface heparan sulfate proteoglycans control the response of renal interstitial fibroblasts to fibroblast growth factor-2. Kidney International 59 (6) , pp. 2084-2094. 10.1046/j.1523-1755.2001.00723.x |
Martin, John, Eynstone, Lisa V., Davies, Malcolm and Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 2001. Induction of metalloproteinases by glomerular mesangial cells stimulated by proteins of the extracellular matrix. Journal of the American Society of Nephrology 12 (1) , pp. 88-96. |
Clayton, Aled ORCID: https://orcid.org/0000-0002-3087-9226 and Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 1999. ICAM-1 interactions in the renal interstitium: a novel activator of fibroblasts during nephritis. Histology and Histopathology 14 (3) , pp. 861-870. |
Clayton, Aled ORCID: https://orcid.org/0000-0002-3087-9226, Thomas, Janet, Thomas, Gareth, Davies, Malcolm and Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 1999. Fibroblasts from the cortical interstitium express cell surface heparan sulphate proteoglycans [Abstract]. Kidney International 55 (6) , p. 2588. 10.1046/j.1523-1755.2002.t01-1-00456.x |
Evans, R. E., Clayton, Aled ORCID: https://orcid.org/0000-0002-3087-9226, Martin, J., Williams, J. D., Davies, M. and Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 1999. Neutrophil binding stimulates the synthesis, release and activation of MMP 3 and MMP 2 from endothelial cells in vitro [Abstract]. Kidney International 55 (5) , p. 2105. 10.1046/j.1523-1755.1999.00404.x |
Clayton, Aled ORCID: https://orcid.org/0000-0002-3087-9226, Evans, Rachel A., Pettit, Elizabeth, Hallett, Maurice, Williams, John David and Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 1998. Cellular activation through the ligation of intercellular adhesion molecule-1. Journal of Cell Science 111 (4) , pp. 443-453. |
Clayton, Aled ORCID: https://orcid.org/0000-0002-3087-9226, Williams, J. D. and Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 1997. The ligation of ICAM-1 on renal cortical fibroblasts initiates the de novo expression of ICAM-1 and VCAM-1. Journal of the American Society of Nephrology 8 , A2385-A2385. |
Evans, R. A., Clayton, Aled ORCID: https://orcid.org/0000-0002-3087-9226, Martin, J., Williams, J. D., Davies, M. and Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 1997. Neutrophil binding stimulates the synthesis, release and activation of MMP 2 from endothelial cells in vitro. Journal of the American Society of Nephrology 8 , A2390-A2390. |
Clayton, Aled ORCID: https://orcid.org/0000-0002-3087-9226, Williams, J. D. and Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 1997. Ligation of ICAM-1 on the surface of renal cortical fibroblasts stimulates de novo expression of ICAM-1 and VCAM-1 [Abstract]. Kidney International 52 (1) , pp. 262-263. 10.1038/ki.1997.329 |
Clayton, Aled ORCID: https://orcid.org/0000-0002-3087-9226, Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 and Williams, John David 1997. Cells isolated from the human cortical interstitium resemble myofibroblasts and bind neutrophils in an ICAM-1--dependent manner. Journal of the American Society of Nephrology 8 (4) , pp. 604-615. |
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Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496, Topley, Nicholas, MacKenzie, Ruth Kathryn, Davies, M. and Williams, John David 1988. Scarring potential, fimbrial type-alpha-hemolysin production and human neutrophil (pmn) activation by uropathogenic strains of escherichia-coli [Abstract]. Kidney International 33 (1) , p. 325. |