Divergent evolutionary rates of primate brain regions as revealed by genomics and transcriptomics

Zhuang, Xiao-Lin, Shao, Yong, Chen, Chun-Yan, Zhou, Long, Yao, Yong-Gang, Cooper, David N. ORCID: https://orcid.org/0000-0002-8943-8484, Zhang, Guo-Jie, Wang, Wen and Wu, Dong-Dong 2024. Divergent evolutionary rates of primate brain regions as revealed by genomics and transcriptomics. Genome Biology and Evolution 16 (2) , evae023. 10.1093/gbe/evae023

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Abstract

Although the primate brain contains numerous functionally distinct structures that have experienced diverse genetic changes during the course of evolution and development, these changes remain to be explored in detail. Here we utilize two classic metrics from evolutionary biology, the evolutionary rate index (ERI) and the transcriptome age index (TAI), to investigate the evolutionary alterations that have occurred in each area and developmental stage of the primate brain. We observed a higher evolutionary rate for those genes expressed in the non-cortical areas during primate evolution, particularly in human, with the highest rate of evolution being exhibited at brain developmental stages between late infancy and early childhood. Further, the transcriptome age of the non-cortical areas was lower than that of the cerebral cortex, with the youngest age apparent at brain developmental stages between late infancy and early childhood. Our exploration of the evolutionary patterns manifest in each brain area and developmental stage provides important reference points for further research into primate brain evolution.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Additional Information:	License information from Publisher: LICENSE 1: URL: https://creativecommons.org/licenses/by/4.0/, Type: cc-by
Publisher:	Oxford University Press
ISSN:	1759-6653
Date of First Compliant Deposit:	22 February 2024
Date of Acceptance:	30 January 2024
Last Modified:	22 Feb 2024 13:00
URI:	https://orca.cardiff.ac.uk/id/eprint/166486

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