Reactive oxygen species and its role in pathogenesis and resistance to therapy in acute myeloid leukemia

Sorouri Khorashad, Jamsid, Rizzo, Sian and Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 2024. Reactive oxygen species and its role in pathogenesis and resistance to therapy in acute myeloid leukemia. Cancer Drug Resistance 7 , 5. 10.20517/cdr.2023.125

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Abstract

Relapse following a short clinical response to therapy is the major challenge for the management of acute myeloid leukemia (AML) patients. Leukemic stem cells (LSC), as the source of relapse, have been investigated for their metabolic preferences and their alterations at the time of relapse. As LSC rely on oxidative phosphorylation (OXPHOS) for energy requirement, reactive oxygen species (ROS), as by-products of OXPHOS, have been investigated for their role in the effectiveness of the standard AML therapy. Increased levels of non-mitochondrial ROS, generated by nicotinamide adenine dinucleotide phosphate oxidase, in a subgroup of AML patients add to the complexity of studying ROS. Although there are various studies presenting the contribution of ROS to AML pathogenesis, resistance, and its inhibition or activation as a target, a model that can clearly explain its role in AML has not been conceptualized. This is due to the heterogeneity of AML, the dynamics of ROS production, which is influenced by factors such as the type of treatment, cell differentiation state, mitochondrial activity, and also the heterogeneous generation of non-mitochondrial ROS and limited available data on their interaction with the microenvironment. This review summarizes these challenges and the recent progress in this field.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	OAE Publishing
ISSN:	2578-532X
Date of First Compliant Deposit:	8 April 2024
Date of Acceptance:	19 February 2024
Last Modified:	15 Apr 2024 10:38
URI:	https://orca.cardiff.ac.uk/id/eprint/167799

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