Richards, Nigel G. J.  ORCID: https://orcid.org/0000-0002-0375-0881 and Naismith, James H.
2024.
The chemistry of Formycin biosynthesis.
Frontiers in Chemical Biology
3
, 1428646.
10.3389/fchbi.2024.1428646
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License URL: http://creativecommons.org/licenses/by/4.0/
License Start date: 12 July 2024
Official URL: http://dx.doi.org/10.3389/fchbi.2024.1428646
Abstract
Remarkable progress has been made to elucidate the structural and mechanistic enzymology of the biosynthetic pathways that give rise to naturally occurring C-nucleosides. These compounds are generally cytotoxic and exhibit interesting antiviral, antibiotic and anti-parasitic activity. Here we review current knowledge concerning formycin biosynthesis and highlight deficiencies in our understanding of key chemical transformations in the pathway.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Chemistry |
| Publisher: | Frontiers Media |
| ISSN: | 2813-530X |
| Funders: | BBSRC |
| Date of First Compliant Deposit: | 17 July 2024 |
| Date of Acceptance: | 24 June 2024 |
| Last Modified: | 01 Aug 2024 11:06 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/170637 |
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