The chemistry of Formycin biosynthesis

Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 and Naismith, James H. 2024. The chemistry of Formycin biosynthesis. Frontiers in Chemical Biology 3 , 1428646. 10.3389/fchbi.2024.1428646

Preview

PDF - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview

Abstract

Remarkable progress has been made to elucidate the structural and mechanistic enzymology of the biosynthetic pathways that give rise to naturally occurring C-nucleosides. These compounds are generally cytotoxic and exhibit interesting antiviral, antibiotic and anti-parasitic activity. Here we review current knowledge concerning formycin biosynthesis and highlight deficiencies in our understanding of key chemical transformations in the pathway.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	Frontiers Media
ISSN:	2813-530X
Funders:	BBSRC
Date of First Compliant Deposit:	17 July 2024
Date of Acceptance:	24 June 2024
Last Modified:	01 Aug 2024 11:06
URI:	https://orca.cardiff.ac.uk/id/eprint/170637

Actions (repository staff only)

Edit Item