Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Browse by Current Cardiff authors

[up] Up a level
Number of items: 41.

Coricello, Adriana, Nardone, Alanya J., Lupia, Antonio, Gratteri, Carmen, Vos, Matthijn, Chaptal, Vincent, Alcaro, Stefano, Zhu, Wen, Takagi, Yuichiro and Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 2024. 3D variability analysis reveals a hidden conformational change controlling ammonia transport in human asparagine synthetase. Nature Communications 15 (1) , 10538. 10.1038/s41467-024-54912-9
filefilefilefile

Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 and Naismith, James H. 2024. The chemistry of Formycin biosynthesis. Frontiers in Chemical Biology 3 , 1428646. 10.3389/fchbi.2024.1428646
file

Falcioni, Fabio, Molt, Robert W., Jin, Yi, Waltho, Jonathan P., Hay, Sam, Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 and Blackburn, G. Michael 2024. Arginine kinase activates Arginine for phosphorylation by pyramidalization and polarization. ACS Catalysis 14 (9) , 6650–6658. 10.1021/acscatal.4c00380
file

Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881, Bearne, Stephen L., Goto, Yuki and Parker, Emily J. 2023. Reactivity and mechanism in chemical and synthetic biology. Philosophical Transactions of the Royal Society B: Biological Sciences 378 (1871) , 20220023. 10.1098/rstb.2022.0023
file

Li, Wenbo, Girt, Georgina C., Radadiya, Ashish ORCID: https://orcid.org/0000-0001-7348-1755, Stewart, James J. P., Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 and Naismith, James H. 2023. Experimental and computational snapshots of C-C bond formation in a C-nucleoside synthase. Open Biology 13 (1) , 220287. 10.1098/rsob.220287
file

Bijani, Sabera, Shaikh, Faraz, Mirza, Sheefa, Weng In Siu, Shirley, Jain, Nayan, Rawal, Rakesh, Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881, Shah, Anamik and Radadiya, Ashish ORCID: https://orcid.org/0000-0001-7348-1755 2022. Novel dihydropyrimidinone derivatives as potential P-glycoprotein modulators. ACS Omega 7 (19) , pp. 16278-16287. 10.1021/acsomega.1c05839
file

Riegert, Alexander S., Narindoshvili, Tamari, Coricello, Adriana, Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 and Raushel, Frank M. 2021. Functional characterization of two PLP-dependent enzymes involved in capsular polysaccharide biosynthesis from campylobacter jejuni. Biochemistry 60 (37) , 2836–2843. 10.1021/acs.biochem.1c00439
file

Ouaray, Zahra, Benner, Steven A., Georgiadis, Millie M. and Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 2020. Building better polymerases: Engineering the replication of expanded genetic alphabets. Journal of Biological Chemistry 295 (50) , pp. 17046-17059. 10.1074/jbc.REV120.013745
file

Radadiya, Ashish ORCID: https://orcid.org/0000-0001-7348-1755, Zhu, Wen, Coricello, Adriana, Alcaro, Stefano and Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 2020. Improving the treatment of acute lymphoblastic leukemia. Biochemistry 59 (35) , pp. 3193-3200. 10.1021/acs.biochem.0c00354
file

Gao, Sisi, Radadiya, Ashish ORCID: https://orcid.org/0000-0001-7348-1755, Li, Wenbo, Liu, Huanting, Zhu, Wen, de Crécy-Lagard, Valérie, Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 and Naismith, James H. 2020. Uncovering the chemistry of C–C bond formation in C-nucleoside biosynthesis: crystal structure of a C-glycoside synthase/PRPP complex. Chemical Communications 56 (55) , pp. 7617-7620. 10.1039/D0CC02834G
file

Eberlein, Lukas, Beierlein, Frank R., van Eikema Hommes, Nico J.R., Radadiya, Ashish ORCID: https://orcid.org/0000-0001-7348-1755, Heil, Jochen, Benner, Steven A., Clark, Timothy, Kast, Stefan M. and Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 2020. Tautomeric equilibria of nucleobases in the hachimoji expanded genetic alphabet. Journal of Chemical Theory and Computation 16 (4) , pp. 2766-2777. 10.1021/acs.jctc.9b01079
file

Zhu, Wen, Liu, Xuan, Hughes, Margaret, de Crécy-Lagard, Valérie and Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 2020. Whole-genome sequence of Streptomyces kaniharaensis Shomura and Niida SF-557. Microbiology Resource Announcements 9 (14) , e01434-19. 10.1128/MRA.01434-19
file

Ouaray, Zahra, Singh, Isha, Georgiadis, Millie M. and Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 2020. Building better enzymes: molecular basis of improved non-natural nucleobase incorporation by an evolved DNA polymerase. Protein Science 29 (2) 10.1002/pro.3762
file

Gao, Sisi, Liu, Huanting, de Crécy-Lagard, Valérie, Zhu, Wen, Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 and Naismith, James H. 2019. PMP-diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis. Chemical Communications 55 (96) , pp. 14502-14505. 10.1039/C9CC06975E
file

Zhu, Wen, Radadiya, Ashish ORCID: https://orcid.org/0000-0001-7348-1755, Bisson, Claudine, Wenzel, Sabine, Nordin, Brian E., Martínez-Márquez, Francisco, Imasaki, Tsuyoshi, Sedelnikova, Svetlana E., Coricello, Adriana, Baumann, Patrick, Berry, Alexandria H., Nomanbhoy, Tyzoon K., Kozarich, John W., Jin, Yi ORCID: https://orcid.org/0000-0002-6927-4371, Rice, David W., Takagi, Yuichiro and Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 2019. Author correction: High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity. Communications Biology 2 (1) , 438. 10.1038/s42003-019-0690-1
file

Zhu, Wen, Radadiya, Ashish ORCID: https://orcid.org/0000-0001-7348-1755, Bisson, Claudine, Wenzel, Sabine, Nordin, Brian E., Martínez-Márquez, Francisco, Imasaki, Tsuyoshi, Sedelnikova, Svetlana E., Coricello, Adriana, Baumann, Patrick, Berry, Alexandria H., Nomanbhoy, Tyzoon K., Kozarich, John W., Jin, Yi ORCID: https://orcid.org/0000-0002-6927-4371, Rice, David W., Takagi, Yuichiro and Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 2019. High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity. Communications Biology 2 , 345. 10.1038/s42003-019-0587-z
file

Zhu, Wen, Reinhardt, Laurie A. and Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 2018. Second-shell hydrogen bond impacts transition-state structure in bacillus subtilis oxalate decarboxylase. Biochemistry 57 (24) , pp. 3425-3432. 10.1021/acs.biochem.8b00214
file

Jin, Yi ORCID: https://orcid.org/0000-0002-6927-4371, Molt Jr., Robert W., Pellegrini, Erika, Cliff, Matthew J., Bowler, Matthew W., Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881, Blackburn, G. Michael and Waltho, Jonathan P. 2017. Assessing the influence of mutation on GTPase transition states by using x-ray crystallography, 19F NMR, and DFT approaches. Angewandte Chemie International Edition 56 (33) , pp. 9732-9735. 10.1002/anie.201703074
file

Malhotra, Shashwat, Singh, Seema, Rana, Neha, Tomar, Shilpi, Bhatnagar, Priyanka, Gupta, Mohit, Singh, Suraj K., Singh, Brajendra K., Chhillar, Anil K., Prasad, Ashok K., Len, Christophe, Kumar, Pradeep, Gupta, Kailash C., Varma, Anjani J., Kuhad, Ramesh C., Sharma, Gainda L., Parmar, Virinder S. and Richards, Nigel ORCID: https://orcid.org/0000-0002-0375-0881 2017. Chemoenzymatic synthesis, nanotization and anti- aspergillus activity of optically enriched fluconazole analogues. Antimicrobial Agents and Chemotherapy 61 (8) , e00273-17. 10.1128/AAC.00273-17
file

Sheng, Xiang, Zhu, Wen, Huddleston, Jamison, Xiang, Dao Fen, Raushel, Frank M., Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 and Himo, Fahmi 2017. A combined experimental-theoretical study of the ligW-catalyzed decarboxylation of 5-carboxyvanillate in the metabolic pathway for lignin degradation. ACS Catalysis 7 (8) , pp. 4968-4974. 10.1021/acscatal.7b01166
file

Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 and Georgiadis, Millie M. 2017. Toward an expanded genome: structural and computational characterization of an artificially expanded genetic information system. Accounts of Chemical Research 50 (6) , pp. 1375-1382. 10.1021/acs.accounts.6b00655
file

Zhu, Wen and Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 2017. Biological functions controlled by manganese redox changes in mononuclear Mn-dependent enzymes. Essays in Biochemistry 61 (2) , pp. 259-270. 10.1042/EBC20160070
file

Blackburn, G. Michael, Cherfils, Jacqueline, Moss, Gerard P., Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881, Waltho, Jonathan P., Williams, Nicholas H. and Wittinghofer, Alfred 2017. How to name atoms in phosphates, polyphosphates, their derivatives and mimics, and transition state analogues for enzyme-catalysed phosphoryl transfer reactions (IUPAC Recommendations 2016). Pure and Applied Chemistry 89 (5) , pp. 653-675. 10.1515/pac-2016-0202
file

Molt, Robert, Georgiadis, Millie M. and Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 2017. Consecutive non-natural PZ nucleobase pairs in DNA impact helical structure as seen in 50 μs molecular dynamics simulations. Nucleic Acids Research 45 (7) , pp. 3643-3653. 10.1093/nar/gkx144
file

Jin, Yi ORCID: https://orcid.org/0000-0002-6927-4371, Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881, Waltho, Jonathan P. and Blackburn, G. Michael 2017. Metal fluorides as analogues for studies on phosphoryl transfer enzymes. Angewandte Chemie - International Edition 56 (15) , pp. 4110-4128. 10.1002/anie.201606474
file

Blackburn, George Michael, Jin, Yi ORCID: https://orcid.org/0000-0002-6927-4371, Richards, Nigel G.J. ORCID: https://orcid.org/0000-0002-0375-0881 and Waltho, Jonathan P 2017. Metal fluorides as analogs for studies on phosphoryl transfer enzymes. Angewandte Chemie 129 (15) , pp. 4172-4192. 10.1002/ange.201606474
file

Kumar, Amit, Khan, Abdullah, Malhotra, Shashwat, Mosurkal, Ravi, Dhawan, Ashish, Pandey, Mukesh K., Singh, Brajendra K., Kumar, Rajesh, Prasad, Ashok K., Sharma, Sunil K., Samuelson, Lynne A., Cholli, Ashok L., Len, Christophe, Richards, Nigel G.J. ORCID: https://orcid.org/0000-0002-0375-0881, Kumar, Jayant, Haag, Rainer, Watterson, Arthur C. and Parmar, Virinder S. 2016. Synthesis of macromolecular systems via lipase catalyzed biocatalytic reactions: applications and future perspectives. Chemical Society Reviews 45 (24) , pp. 6855-6887. 10.1039/C6CS00147E
file

Molt, Robert, Watson, Thomas, Bazanté, Alexandre P., Bartlett, Rodney J. and Richards, Nigel G.J. ORCID: https://orcid.org/0000-0002-0375-0881 2016. Gas phase RDX decomposition pathways using coupled cluster theory. Physical Chemistry Chemical Physics 18 (37) , pp. 26069-26077. 10.1039/C6CP05121A
file

Zhu, Wen, Easthon, Lindsey M., Reinhardt, Laurie A., Tu, Chingkuang, Cohen, Steven E., Silverman, David N, Allen, Karen N and Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 2016. Substrate binding mode and molecular basis of a specificity switch in oxalate decarboxylase. Biochemistry 85 (14) , pp. 2163-2173. 10.1021/acs.biochem.6b00043
file

Jin, Yi ORCID: https://orcid.org/0000-0002-6927-4371, Molt Jr, Robert W., Waltho, Jonathan P., Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 and Blackburn, G. Michael 2016. 19F NMR and DFT analysis reveal structural and electronic transition state features for RhoA-catalyzed GTP hydrolysis. Angewandte Chemie International Edition 55 (10) , pp. 3318-3322. 10.1002/anie.201509477
file

Kumar, Prashant, Singh, Anil K., Bahadur, Vijay, Len, Christophe, Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881, Parmar, Virinder S., Van der Eycken, Erik V. and Singh, Brajendra K. 2016. Microwave-assisted, metal-free, base-mediated C-N bond formation/cleavage: synthesis of benzimidazo[1,2-a]quinazoline derivatives. ACS Sustainable Chemistry & Engineering 4 (4) , pp. 2206-2210. 10.1021/acssuschemeng.5b01669

Vladimirova, Anna, Patskovsky, Yury, Fedorov, Alexander A., Bonanno, Jeffrey B., Fedorov, Elena V., Toro, Rafael, Hillerich, Brandan, Seidel, Ronald D., Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881, Almo, Steven C. and Raushel, Frank M. 2016. Substrate distortion and the catalytic reaction mechanism of 5-carboxyvanillate decarboxylase. Journal of the American Chemical Society 138 (3) , pp. 826-836. 10.1021/jacs.5b08251
file

Zhu, Wen, Wilcoxen, Jarett, Britt, R. David and Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 2016. Formation of hexacoordinate Mn(III) in Bacillus subtilis oxalate decarboxylase requires catalytic turnover. Biochemistry 55 (3) , pp. 429-434. 10.1021/acs.biochem.5b01340

Sharma, Pramod K., Balwani, Sakshi, Mathur, Divya, Malhotra, Shashwat, Singh, Brajendra K., Prasad, Ashok K., Len, Christophe, Van der Eycken, Erik V., Ghosh, Balaram, Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 and Parmar, Virinder S. 2016. Synthesis and anti-inflammatory activity evaluation of novel triazolyl-isatin hybrids. Journal of Enzyme Inhibition and Medicinal Chemistry 31 (6) , pp. 1520-1526. 10.3109/14756366.2016.1151015

Hettmer, Simone, Schinzel, Anna C., Tchessalova, Daria, Schneider, Michaela, Parker, Christina L., Bronson, Roderick T., Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881, Hahn, William C. and Wagers, Amy J. 2015. Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma. eLife 4 , e09436.. 10.7554/eLife.09436
file

Georgiadis, Millie M., Singh, Isha, Kellett, Whitney F., Hoshika, Shuichi, Benner, Steven A. and Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 2015. Structural basis for a six nucleotide genetic alphabet. Journal of the American Chemical Society 137 (21) , pp. 6947-6955. 10.1021/jacs.5b03482

Molt Jr., Robert W., Lecher, Alison M., Clark, Timothy, Bartlett, Rodney J. and Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 2015. Facile Csp2-Csp2 bond cleavage in oxalic acid-derived radicals. Journal of the American Chemical Society 137 (9) , pp. 3248-3252. 10.1021/ja510666r

Twahir, Umar T., Stedwell, Corey N., Lee, Cory T., Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881, Polfer, Nicolas C. and Angerhofer, Alexander 2015. Observation of superoxide production during catalysis of Bacillus subtilis oxalate decarboxylase at pH 4. Free Radical Biology and Medicine 80 , p. 59. 10.1016/j.freeradbiomed.2014.12.012
file

Miao, J, Richards, Nigel ORCID: https://orcid.org/0000-0002-0375-0881 and Ge, H 2014. Rhodium-catalyzed direct synthesis of unprotected NH-sulfoximines from sulfoxides. Chemical Communications- Royal Society of Chemistry 50 (68) , pp. 9687-9689. 10.1039/c4cc04349a

Brunk, E, Kellett, W.F., Richards, Nigel ORCID: https://orcid.org/0000-0002-0375-0881 and Rothlisberger, U 2014. A mechanochemical switch to control radical intermediates. Biochemistry 53 (23) , pp. 3830-3838. 10.1021/bi500050k

Campomanes, Pablo, Kellett, Whitney F., Easthon, Lindsey M., Ozarowski, Andrew, Allen, Karen N., Angerhofer, Alexander, Rothlisberger, Ursula and Richards, Nigel G. J. ORCID: https://orcid.org/0000-0002-0375-0881 2014. Assigning the EPR fine structure parameters of the Mn(II) centers in bacillus subtilis oxalate decarboxylase by site-directed mutagenesis and DFT/MM calculations. Journal of the American Chemical Society 136 (6) , pp. 2313-2323. 10.1021/ja408138f
file

This list was generated on Sat Mar 8 05:23:13 2025 GMT.


Maintained by Cardiff University Information Services