Immunocytochemical localization of oestrogen and progesterone receptors in primary adenocarcinoma of the cervix

Ghandour, F. A., Attanoos, Richard L., Nahar, K., Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015, Bigrigg, A. and Ismail, Sezgin M. 1994. Immunocytochemical localization of oestrogen and progesterone receptors in primary adenocarcinoma of the cervix. Histopathology 24 (1) , pp. 49-55. 10.1111/j.1365-2559.1994.tb01270.x

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Abstract

Archival material from 47 primary invasive adenocarcinomas of the uterine cervix was examined using an immunocytochemical technique for detection of oestrogen receptor and progesterone receptor in paraffin-wax embedded tissues. Immunostaining for oestrogen receptor was noted within tumour cells in 12 cervical adenocarcinomas while 13 tumours contained progesterone receptor. Eleven cervical adenocarcinomas expressed both oestrogen and progesterone receptor simultaneously. There was no association between steroid receptor status and major histological subtype, grade of tumour, clinical stage or age of patient at presentation. However, oestrogen receptor immunoreactivity was associated with disease-free survival. This preliminary study raises the possibility that, as in breast carcinoma, steroid receptor status may be a useful prognostic factor in adenocarcinoma of the cervix.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Pharmacy
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	cervix; adenocarcinoma; oestrogen receptors; progesterone receptors; immunohistochemistry
Publisher:	Wiley-Blackwell
ISSN:	0309-0167
Last Modified:	18 Oct 2022 14:18
URI:	https://orca.cardiff.ac.uk/id/eprint/17122

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