A systematic review of estrogen modulators as augmentation to antipsychotics for the treatment of post- and perimenopausal psychosis [Abstract]

Keen, Cassidy, Hassoulas, Athanasios ORCID: https://orcid.org/0000-0002-1029-1847 and Richardson, Jill 2024. A systematic review of estrogen modulators as augmentation to antipsychotics for the treatment of post- and perimenopausal psychosis [Abstract]. BJPsych Open 10 (S1) , S50-S51. 10.1192/bjo.2024.180

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Abstract

Aims To investigate if estrogen agents as an adjunct to antipsychotic medication are effective at treating psychosis in post-and perimenopausal females. Methods A digital search focusing on controlled clinical trials was conducted. Studies were assessed for quality using the Cochrane Risk of Bias tool and GRADE system. The Joanna Briggs Institute (JBI) tools were used to critically appraise articles. The total Positive and Negative Symptom Scale (PANSS) scores were synthesised using a meta-analysis. Results Of the studies obtained (n = 11), two used estrogen HT as an augmentation agent, and nine used the SERM Raloxifene. Quality review and critical appraisal found inconsistencies in data and publication bias favouring trials that include Raloxifene. Meta-analysis results indicate Raloxifene plus antipsychotic did perform better than placebo [Std diff in means total = 0.340 (95% CI) p = 0.001] with a small effect size (g = 0.3392). Conclusion Though research appears promising, recommendations for the use of estrogen agent augmentation cannot be made at this time as more clinical trials that include a diverse range of treatments are needed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RZ Other systems of medicine
Publisher:	Cambridge University Press
ISSN:	2056-4724
Date of First Compliant Deposit:	18 September 2024
Date of Acceptance:	1 August 2024
Last Modified:	18 Sep 2024 10:30
URI:	https://orca.cardiff.ac.uk/id/eprint/171281

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