Epidermal growth factor receptor expression in breast cancer: Association with response to endocrine therapy

Nicholson, Robert Ian, McClelland, Richard Andrew, Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015, Manning, David L., Cannon, P., Robertson, J. F. R., Ellis, I. O. and Blamey, R. W. 1994. Epidermal growth factor receptor expression in breast cancer: Association with response to endocrine therapy. Breast Cancer Research and Treatment 29 (1) , pp. 117-125. 10.1007/BF00666187

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Abstract

106 previously untreated breast cancer patients have been immunohistochemically analysed for EGF-R, ER, Ki67, and c-erbB-2 product. All patients received assessable endocrine therapy following disease progression. Significant associations were observed between EGF-R and ER (inverse) and Ki67 (direct). No association was observed between EGF-R and the c-erbB-2 product. EGF-R expression was significantly associated with the loss of endocrine sensitivity in breast cancer. This was observed in both ER positive and negative disease. In ER positive breast cancers, EGF-R expression had no significant influence on the quality of tumour remissions. Further sub-classification of the ER/EGF-R data by Ki67 immunostaining showed that in ER+/EGF-R- disease, increasing proportions of Ki67 positive cells were associated with a decline in the numbers of women experiencing good quality tumour remissions. A similar trend was also observed in ER+/EGF-R+ tumours. The presence of c-erbB-2 protein product did not influence endocrine sensitivity in any of the ER/EGF-R sub-groups.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	breast cancer - endocrine therapy - epidermal growth factor receptor - estrogen receptor - Ki67 - c-erbB-2
Publisher:	Springer Verlag
ISSN:	0167-6806
Last Modified:	18 Oct 2022 14:19
URI:	https://orca.cardiff.ac.uk/id/eprint/17132

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