Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Modulation of oestrogen action by receptor gene inhibition

Madden, Tracie-Ann ORCID:, Barrow, Denise, McClelland, Richard Andrew, Gee, Julia Margaret Wendy ORCID: and Nicholson, Robert Ian 2000. Modulation of oestrogen action by receptor gene inhibition. European Journal of Cancer 36 (S4) , pp. 34-35. 10.1016/S0959-8049(00)00216-1

Full text not available from this repository.


Selective oestrogen receptor downregulators (SERDs) are a class of highly effective steroidal antitumour agents that reduce cellular levels of the oestrogen receptor (ER). In this study, we compared the efficacy by which three novel molecular approaches: (1) antisense oligonucleotides; (2) antisense RNA; and (3) dominant negative mutants are able to act as SERDs. Using transient and, where appropriate, stable gene transfection experiments we found that constitutive overexpression of ER antisense RNA and a hormone-binding domain compromised dominant-negative ER mutant (DNER-1), were most effective at downregulating ER expression and/or activity in vitro.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: Breast cancer; Oestrogen receptor; Antisense; Dominant-negative; Gene inhibition
Publisher: Elsevier
ISSN: 0014-2964
Last Modified: 18 Oct 2022 14:20

Citation Data

Cited 5 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item