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Modulation of epidermal growth factor receptor in endocrine-resistant, estrogen-receptor-positive breast cancer

Nicholson, Robert Ian, Hutcheson, Iain Robert, Harper, Maureen Elaine, Knowlden, Janice Mary, Barrow, Denise, McClelland, Richard Andrew, Jones, Helen E., Wakeling, A. E. and Gee, Julia Margaret Wendy ORCID: 2002. Modulation of epidermal growth factor receptor in endocrine-resistant, estrogen-receptor-positive breast cancer. Castagnetta, L., Agostara, B., Massimo, L., Montalto, G. and Bradlow, H. L., eds. Hormone-Related Tumors: Novel Approaches to Prevention and Treatment, Annals of the New York Academy of Sciences, vol. 963. New York: The New York Academy of Sciences, pp. 104-115. (10.1111/j.1749-6632.2002.tb04101.x)

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n increasing body of evidence demonstrates that growth factor networks are highly interactive with estrogen receptor signaling in the control of breast cancer growth. As such, tumor responses to antihormones are likely to be a composite of the estrogen receptor and growth factor inhibitory activity of these agents. The modulation of growth factor networks during endocrine response is examined, and in vitro and clinical evidence is presented that epidermal growth factor receptor signaling, maintained in either an estrogen receptor-dependent or a receptor-independent manner, is critical to antihormone-resistant breast cancer cell growth. The considerable potential of the epidermal growth factor receptor-selective tyrosine kinase inhibitor Iressa (ZD 1839) to efficiently treat, and perhaps even prevent, endocrine-resistant breast cancer is highlighted.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: breast cancer; estrogen receptor; tyrosine kinase inhibitor; ZD 1839
Publisher: The New York Academy of Sciences
ISBN: 9780801878299
Last Modified: 18 Oct 2022 14:20

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