Oxylipin profiling for clinical research: Current status and future perspectives

Parchem, Karol, Letsiou, Sophia, Petan, Toni, Oskolkova, Olga, Medina, Isabel, Kuda, Ondrej, O'Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460, Nicolaou, Anna, Fedorova, Maria, Bochkov, Valery and Gladine, Cécile 2024. Oxylipin profiling for clinical research: Current status and future perspectives. Progress in Lipid Research 95 , 101276. 10.1016/j.plipres.2024.101276

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Abstract

Oxylipins are potent lipid mediators with increasing interest in clinical research. They are usually measured in systemic circulation and can provide a wealth of information regarding key biological processes such as inflammation, vascular tone, or blood coagulation. Although procedures still require harmonization to generate comparable oxylipin datasets, performing comprehensive profiling of circulating oxylipins in large studies is feasible and no longer restricted by technical barriers. However, it is essential to improve and facilitate the biological interpretation of complex oxylipin profiles to truly leverage their potential in clinical research. This requires regular updating of our knowledge about the metabolism and the mode of action of oxylipins, and consideration of all factors that may influence circulating oxylipin profiles independently of the studied disease or condition. This review aims to provide the readers with updated and necessary information regarding oxylipin metabolism, their different forms in systemic circulation, the current limitations in deducing oxylipin cellular effects from in vitro bioactivity studies, the biological and technical confounding factors needed to consider for a proper interpretation of oxylipin profiles.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Elsevier
ISSN:	0163-7827
Date of First Compliant Deposit:	13 September 2024
Date of Acceptance:	29 April 2024
Last Modified:	16 Sep 2024 14:00
URI:	https://orca.cardiff.ac.uk/id/eprint/172079

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