Cancer immunotherapy by γδ T cells

Hayday, Adrian, Dechanet-Merville, Julie, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522 and Silva-Santos, Bruno 2024. Cancer immunotherapy by γδ T cells. Science 386 (6717) , eabq7248. 10.1126/science.abq7248

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Abstract

The premise of cancer immunotherapy is that cancers are specifically visible to an immune system tolerized to healthy self. The promise of cancer immunotherapy is that immune effector mechanisms and immunological memory can jointly eradicate cancers and inoperable metastases and de facto vaccinate against recurrence. For some patients with hitherto incurable diseases, including metastatic melanoma, this promise is being realized by game-changing immunotherapies based on αβ T cells. Today’s challenges are to bring benefit to greater numbers of patients of diverse ethnicities, target more cancer types, and achieve a cure while incurring fewer adverse events. In meeting those challenges, specific benefits may be offered by γδ T cells, which compose a second T cell lineage with distinct recognition capabilities and functional traits that bridge innate and adaptive immunity. γδ T cell–based clinical trials, including off-the-shelf adoptive cell therapy and agonist antibodies, are yielding promising results, although identifiable problems remain. In addressing those problems, we advocate that immunotherapies be guided by the distinctive biology of γδ T cells, as elucidated by ongoing research.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Publisher:	American Association for the Advancement of Science
ISSN:	0036-8075
Date of Acceptance:	22 August 2024
Last Modified:	17 Oct 2024 13:45
URI:	https://orca.cardiff.ac.uk/id/eprint/173058

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