Wang, Hongyu, Bai, Ran, Wang, Yubing, Qu, Meihua, Zhou, You  ORCID: https://orcid.org/0000-0002-1743-1291, Gao, Zhiqin and Wang, Yi
2025.
The multifaceted function of FoxO1 in pancreatic β-cell dysfunction and insulin resistance: Therapeutic potential for type 2 diabetes.
Life Sciences
364
, 123384.
10.1016/j.lfs.2025.123384
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Abstract
The forkhead box O1 (FOXO1), the first discovered member of the FoxO family, is a critical transcription factor predominantly found in insulin-secreting and insulin-sensitive tissues. In the pancreas of adults, FoxO1 expression is restricted to islet β cells. We determined that in human islet microarray datasets, FoxO1 expression is higher than other FoxO transcription factors. Our analyses of three human islet datasets revealed that FoxO1 expression tends to shows a negative correlation with type 2 diabetes and no correlation with body mass index (BMI) between individuals with low levels of HbA (or ND, non-diabetic) and high levels of HbA (or T2D, type 2 diabetes). However, FoxO1 function is multifaceted and mainly regulated by post-translational modifications including phosphorylation and deacetylation that involved in pancreatic β cell function and insulin sensitivity. This study summarized the molecular mechanisms underlying the role of FoxO1 activity in pancreatic β-cell dysfunction and insulin resistance in T2D. In addition, we discussed the therapeutic potential of FoxO1 inhibitors in diabetes treatment. [Abstract copyright: Copyright © 2025. Published by Elsevier Inc.]
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Publisher: | Elsevier |
| ISSN: | 0024-3205 |
| Date of First Compliant Deposit: | 6 February 2025 |
| Date of Acceptance: | 8 January 2025 |
| Last Modified: | 10 Jan 2026 02:45 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/175653 |
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