FUS expression alters the differentiation response to all-trans retinoic acid in NB4 and NB4R2 cells

Walsby, Elisabeth Jane ORCID: https://orcid.org/0000-0001-8523-5017, Gilkes, Amanda Frances, Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976, Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 and Mills, Kenneth Ian 2007. FUS expression alters the differentiation response to all-trans retinoic acid in NB4 and NB4R2 cells. British Journal of Haematology 139 (1) , pp. 94-97. 10.1111/j.1365-2141.2007.06756.x

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Abstract

The FUS gene is overexpressed in acute myeloid leukaemia (AML) patients and has roles in transcription and mRNA processing. We used ectopic expression of FUS and FUS antisense sequences to assess the effect of modulation of FUS expression in all-trans retinoic acid (ATRA)-sensitive (NB4) and insensitive (NB4R2) human acute promyelocytic (APL) cell lines which express the t(15:17) translocation. Growth, viability and differentiation patterns were maintained, but the expression of the FUS antisense construct in both the cell lines altered the response to ATRA: the previously ATRA-sensitive NB4 cells exhibited resistance; whilst the previously resistant NB4R2 cells showed a differentiation response to treatment.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	differentiation; acute leukaemia; morphology; differentiation therapy
Publisher:	Wiley-Blackwell
ISSN:	0007-1048
Last Modified:	17 Oct 2022 08:26
URI:	https://orca.cardiff.ac.uk/id/eprint/177

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