Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Browse by Current Cardiff authors

Number of items: 61.

Rastogi, Namrata, Gonzalez, Juan Bautista Menendez, Srivastava, Vikas, Alanazi, Bader, Alanazi, Rehab N., Hughes, Owen M., O'Neill, Niamh S., Gilkes, Amanda, Ashley, Neil, Deshpande, Sumukh, Andrews, Robert, Mead, Adam, Rodrigues, Neil ORCID: https://orcid.org/0000-0002-1925-7733, Knapper, Steven ORCID: https://orcid.org/0000-0002-6405-4441, Darley, Richard ORCID: https://orcid.org/0000-0003-0879-0724 and Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 2023. Nuclear factor I-C overexpression promotes monocytic development and cell survival in acute myeloid leukemia. Leukemia 37 , pp. 276-287. 10.1038/s41375-022-01801-z
file

Wagstaff, Megan, Tsaponina, Olga, Caalim, Gilian, Greenfield, Hayley, Milton-Harris, Leanne, Mancini, Erika J., Blair, Allison, Heesom, Kate J., Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976, Darley, Richard L. ORCID: https://orcid.org/0000-0003-0879-0724, Roberts, Stefan G. and Morgan, Rhys G. 2023. Crosstalk between β-catenin and WT1 signalling activity in acute myeloid leukemia [Letters to the Editor]. Haematologica 108 (1) 10.3324/haematol.2021.280294
file

Morgan, Huw J., Rees, Elise, Lanfredini, Simone ORCID: https://orcid.org/0000-0002-3160-5120, Powell, Kate A., Gore, Jasmine, Gibbs, Alex, Lovatt, Charlotte, Davies, Gemma E., Olivero, Carlotta ORCID: https://orcid.org/0000-0002-8961-6703, Shorning, Boris Y., Tornillo, Giusy, Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976, Darley, Richard ORCID: https://orcid.org/0000-0003-0879-0724, Wang, Eddie C.Y. ORCID: https://orcid.org/0000-0002-2243-4964 and Patel, Girish K. 2022. CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis. Journal of Clinical Investigation 132 (21) , e150750. 10.1172/JCI150750
file

Menezes, Ana Catarina, Jones, Rachel, Shrestha, Alina, Nicholson, Rachael, Leckenby, Adam, Azevedo, Aleksandra, Davies, Sara, Baker, Sarah ORCID: https://orcid.org/0000-0002-7474-9757, Gilkes, Amanda, Darley, Richard ORCID: https://orcid.org/0000-0003-0879-0724 and Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 2022. Increased expression of RUNX3 inhibits normal human myeloid development. Leukemia 36 , pp. 1769-1780. 10.1038/s41375-022-01577-2
file

Nicholson, Rachael, Menezes, Ana C., Azevedo, Aleksandra, Leckenby, Adam, Davies, Sara, Seedhouse, Claire, Gilkes, Amanda, Knapper, Steven ORCID: https://orcid.org/0000-0002-6405-4441, Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 and Darley, Richard L. ORCID: https://orcid.org/0000-0003-0879-0724 2022. Protein kinase C epsilon overexpression is associated with poor patient outcomes in AML and promotes daunorubicin resistance through p-glycoprotein-mediated drug efflux. Frontiers in Oncology 12 , 840046. 10.3389/fonc.2022.840046
file

Menezes, Ana Catarina, Dixon, Christabel, Scholz, Anna, Nicholson, Rachael, Leckenby, Adam, Azevedo, Aleksandra, Baker, Sarah ORCID: https://orcid.org/0000-0002-7474-9757, Gilkes, Amanda F., Davies, Sara, Darley, Richard L. ORCID: https://orcid.org/0000-0003-0879-0724 and Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 2022. RUNX3 overexpression inhibits normal human erythroid development. Scientific Reports 12 , 1243. 10.1038/s41598-022-05371-z
file

Robinson, Andrew J., Darley, Richard L. ORCID: https://orcid.org/0000-0003-0879-0724 and Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 2021. Reactive oxygen species in leukemias: maintaining cancer cell proliferation via redox signaling and changing metabolic homeostasis. Oncotarget 12 (10) , pp. 952-954. 10.18632/oncotarget.27913
file

Rastogi, Namrata, Baker, Sarah ORCID: https://orcid.org/0000-0002-7474-9757, Man, Stephen ORCID: https://orcid.org/0000-0001-9103-1686, Uger, Robert A., Wong, Mark, Coles, Steve J., Hodges, Marie, Gilkes, Amanda, Knapper, Steven ORCID: https://orcid.org/0000-0002-6405-4441, Darley, Richard ORCID: https://orcid.org/0000-0003-0879-0724 and Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 2021. Use of an anti-CD200 blocking antibody improves immune responses to AML in vitro and in vivo. British Journal of Haematology 193 (1) , pp. 155-159. 10.1111/bjh.17125
file

Robinson, Andrew J., Darley, Richard L. ORCID: https://orcid.org/0000-0003-0879-0724 and Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 2021. Reactive oxygen species and metabolic re-wiring in acute leukemias. Piccaluga, Pier Paolo, ed. Acute Leukemias, IntechOpen, (10.5772/intechopen.94829)
file

Robinson, Andrew J., Hopkins, Goitseone L., Rastogi, Namrata, Hodges, Marie, Doyle, Michelle, Davies, Sara, Hole, Paul S., Omidvar, Nader, Darley, Richard L. ORCID: https://orcid.org/0000-0003-0879-0724 and Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 2020. Reactive oxygen species drive proliferation in acute myeloid leukemia via the glycolytic regulator PFKFB3. Cancer Research 80 (5) , pp. 937-949. 10.1158/0008-5472.CAN-19-1920
file

Alanazi, Bader, Munje, Chinmay R., Rastogi, Namrata, Williamson, Andrew J. K., Taylor, Samuel, Hole, Paul S., Hodges, Marie, Doyle, Michelle, Baker, Sarah ORCID: https://orcid.org/0000-0002-7474-9757, Gilkes, Amanda F., Knapper, Steven ORCID: https://orcid.org/0000-0002-6405-4441, Pierce, Andrew, Whetton, Anthony D., Darley, Richard L. ORCID: https://orcid.org/0000-0003-0879-0724 and Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 2020. Integrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia. Leukemia 34 (2) , pp. 427-440. 10.1038/s41375-019-0596-4
file

Morgan, Rhys G, Ridsdale, Jenna, Payne, Megan, Heesom, Kate J, Wilson, Marieangela C, Davidson, Andrew, Greenhough, Alexander, Davies, Sara, Williams, Ann C, Blair, Allison, Waterman, Marian L, Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 and Darley, Richard L ORCID: https://orcid.org/0000-0003-0879-0724 2019. LEF-1 drives aberrant B-catenin nuclear localization in myeloid leukemia cells. Haematologica 104 , pp. 1365-1377. 10.3324/haematol.2018.202846
file

Wadley, Alex J., Morgan, Rhys G., Darley, Richard L. ORCID: https://orcid.org/0000-0003-0879-0724, Hole, Paul S. and Coles, Steven J. 2019. Using flow cytometry to detect and measure intracellular thiol redox status in viable T cells from heterogeneous populations. Hancock, John T. and Conway, Myra E., eds. Redox-Mediated Signal Transduction: Methods and Protocols, Vol. 1990. Methods in Molecular Biology, New York, NY, USA: Humana Press, pp. 53-70. (10.1007/978-1-4939-9463-2_5)

Munje, Chinmay, Hills, Robert K. ORCID: https://orcid.org/0000-0003-0166-0062, Whetton, Anthony, Burnett, Alan K., Darley, Richard L. ORCID: https://orcid.org/0000-0003-0879-0724 and Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 2015. Cord blood-derived quiescent CD34+ cells are more transcriptionally matched to AML blasts than cytokine-induced normal human hematopoietic CD34+ cells. Gene Expression: International Journal of Molecular and Cellular Science 16 (4) , pp. 169-175. 10.3727/105221615X14399878166159
file

Coles, S. J., Gilmour, M. N., Reid, R., Knapper, S. ORCID: https://orcid.org/0000-0002-6405-4441, Burnett, A. K., Man, S. ORCID: https://orcid.org/0000-0001-9103-1686, Tonks, A. ORCID: https://orcid.org/0000-0002-6073-4976 and Darley, R. L. ORCID: https://orcid.org/0000-0003-0879-0724 2015. The immunosuppressive ligands PD-L1 and CD200 are linked in AML T-cell immunosuppression: identification of a new immunotherapeutic synapse. Leukemia 29 , pp. 1952-1954. 10.1038/leu.2015.62

Agathanggelou, A., Weston, V. J., Perry, T., Davies, N. J., Skowronska, A., Payne, D. T., Fossey, J. S., Oldreive, C. E., Wei, W., Pratt, G., Parry, H., Oscier, D., Coles, Steven, Hole, Paul Spencer, Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724, McMahon, M., Hayes, J. D., Moss, P., Stewart, G., Taylor, A. M. R. and Stankovic, T. 2015. Targeting the ataxia telangiectasia mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants. Haematologica 100 (8) , pp. 1076-1085. 10.3324/haematol.2014.115170

Morgan, Rhys G., Ridsdale, Jenna, Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 and Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 2014. Factors affecting the nuclear localization of β-Catenin in normal and malignant tissue. Journal of Cellular Biochemistry 115 (8) , pp. 1351-1361. 10.1002/jcb.24803

Zabkiewicz, Joanna ORCID: https://orcid.org/0000-0003-0951-3825, Pearn, Lorna, Hills, Robert ORCID: https://orcid.org/0000-0003-0166-0062, Morgan, Rhys G., Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976, Burnett, Alan K. and Darley, Richard ORCID: https://orcid.org/0000-0003-0879-0724 2014. The PDK1 master kinase is over-expressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts. Haematologica 99 (5) , pp. 858-864. 10.3324/haematol.2013.096487

Hole, Paul Spencer, Zabkiewicz, Joanna ORCID: https://orcid.org/0000-0003-0951-3825, Munje, Chinmay, Newton, Zarabeth, Pearn, Lorna, White, Paul Charles ORCID: https://orcid.org/0000-0002-6562-4696, Marquez, Nuria, Hills, Robert Kerrin ORCID: https://orcid.org/0000-0003-0166-0062, Burnett, Alan Kenneth, Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 and Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 2013. Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling. Blood 122 (19) , pp. 3322-3330. 10.1182/blood-2013-04-491944

Morgan, Rhys G., Pearn, Lorna, Liddiard, Kate ORCID: https://orcid.org/0000-0002-0953-1997, Pumford, Sara Louise, Burnett, Alan Kenneth, Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 and Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 2013. γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin. Leukemia 27 (2) , pp. 336-343. 10.1038/leu.2012.221
file

Daud, Siti Sarah, Pumford, Sara L, Gilmour, Marie N., Gilkes, Amanda F., Burnett, Alan Kenneth, Hills, Robert Kerrin ORCID: https://orcid.org/0000-0003-0166-0062, Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 and Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 2012. Identification of the Wnt signalling protein, TCF7L2 as a significantly overexpressed transcription factor in AML [Abstract]. Blood 120 (21) , 1281.

Coles, Steven, Hills, Robert Kerrin ORCID: https://orcid.org/0000-0003-0166-0062, Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964, Burnett, Alan Kenneth, Man, Stephen Tzekwung ORCID: https://orcid.org/0000-0001-9103-1686, Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 and Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 2012. Expression of CD200 on AML blasts directly suppresses memory T-cell function [Letter]. Leukemia 26 (9) , pp. 2148-2151. 10.1038/leu.2012.77

Coles, Steven, Hills, Robert Kerrin ORCID: https://orcid.org/0000-0003-0166-0062, Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964, Burnett, Alan Kenneth, Man, Stephen Tzekwung ORCID: https://orcid.org/0000-0001-9103-1686, Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 and Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 2012. Increased CD200 expression in acute myeloid leukemia is linked with an increased frequency of FoxP3+ regulatory T cells [Letter]. Leukemia 26 (9) , pp. 2146-2148. 10.1038/leu.2012.75
file

Liddiard, Kate ORCID: https://orcid.org/0000-0002-0953-1997, Burnett, Alan Kenneth, Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 and Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 2012. RUNX1-ETO deregulates the proliferation and growth factor responsiveness of human hematopoietic progenitor cells downstream of the myeloid transcription factor, MYCT1 [Letter]. Leukemia 26 (1) , pp. 177-179. 10.1038/leu.2011.188
file

Coles, Steven, Man, Stephen Tzekwung ORCID: https://orcid.org/0000-0001-9103-1686, Hills, Robert Kerrin ORCID: https://orcid.org/0000-0003-0166-0062, Wang, Edward Chyng Yern ORCID: https://orcid.org/0000-0002-2243-4964, Burnett, Alan Kenneth, Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 and Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 2011. CD200 inhibits memory Th1 cell function in acute myeloid leukaemia (AML)[Abstract]. Immunology 135 (S1) , p. 178. 10.1111/j.1365-2567.2011.03534.x

Coles, Steven, Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964, Man, Stephen Tzekwung ORCID: https://orcid.org/0000-0001-9103-1686, Hills, Robert Kerrin ORCID: https://orcid.org/0000-0003-0166-0062, Burnett, Alan Kenneth, Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 and Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 2011. CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia. Leukemia 25 (5) , pp. 792-799. 10.1038/leu.2011.1

Hole, Paul Spencer, Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 and Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 2011. Do reactive oxygen species play a role in myeloid leukemias? Blood 117 (22) , pp. 5816-5826. 10.1182/blood-2011-01-326025

Zabkiewicz, Joanna ORCID: https://orcid.org/0000-0003-0951-3825, Pearn, Lorna, Hills, Robert Kerrin ORCID: https://orcid.org/0000-0003-0166-0062, Morgan, Rhys G., Burnett, Alan Kenneth, Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 and Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 2010. PDK1 overexpression in acute myeloid leukemia; Clinical significance and potential as a therapeutic target [Abstract]. Blood 116 (21) , pp. 892-893.

Morgan, Rhys Gareth, Pearn, Lorna, Liddiard, Kate ORCID: https://orcid.org/0000-0002-0953-1997, Hills, Robert Kerrin ORCID: https://orcid.org/0000-0003-0166-0062, Burnett, Alan Kenneth, Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 and Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 2010. Distinct regulation of beta- and gamma-Catenin throughout hematopoietic development contrasts with their cooperative roles in acute myeloid leukemia [Abstract]. Blood 116 (21) , 1573.

Coles, Steven, Man, Stephen Tzekwung ORCID: https://orcid.org/0000-0001-9103-1686, Hills, Robert Kerrin ORCID: https://orcid.org/0000-0003-0166-0062, Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964, Burnett, Alan Kenneth, Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 and Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 2010. Over-expression of CD200 un acute myeloid leukemia mediates the expansion of regulatory T-lymphocytes and directly inhibits natural killer cell tumor immunity [Abstract]. Blood 116 (21) , p. 218.

Liddiard, Kate ORCID: https://orcid.org/0000-0002-0953-1997, Hills, Robert Kerrin ORCID: https://orcid.org/0000-0003-0166-0062, Burnett, Alan Kenneth, Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 and Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 2010. OGG1 is a novel prognostic indicator in acute myeloid leukaemia. Oncogene 29 (13) , pp. 2005-2012. 10.1038/onc.2009.462

Hole, Paul Spencer, Pearn, Lorna, Tonks, Amanda Jayne ORCID: https://orcid.org/0000-0002-6073-4976, James, Philip Eurig, Burnett, Alan Kenneth, Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 and Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976 2010. Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34+ hematopoietic progenitor cells. Blood 115 (6) , pp. 1238-1246. 10.1182/blood-2009-06-222869

Yang, Jian ORCID: https://orcid.org/0000-0003-2631-4553, Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724, Hallett, Maurice Bartlett ORCID: https://orcid.org/0000-0001-8197-834X and Evans, William Howard 2009. Low connexin channel-dependent intercellular communication in human adult hematopoietic progenitor/stem cells: Probing mechanisms of autologous stem cell therapy. Cell Communication and Adhesion 16 (5-6) , pp. 138-145. 10.3109/15419061003653763

Dewitt, Sharon ORCID: https://orcid.org/0000-0001-8169-8241, Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 and Hallett, Maurice Bartlett ORCID: https://orcid.org/0000-0001-8197-834X 2009. Translocation or just location? Pseudopodia affect fluorescent signals. Journal of Cell Biology 184 (2) , pp. 197-203. 10.1083/jcb.200806047
file

Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976, Pearn, Lorna, Musson, Megan, Gilkes, Amanda F., Mills, Kenneth Ian, Burnett, Alan Kenneth and Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 2007. Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia. Leukemia 21 (12) , pp. 2495-2505. 10.1038/sj.leu.2404961

Walsby, Elisabeth Jane ORCID: https://orcid.org/0000-0001-8523-5017, Gilkes, Amanda Frances, Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976, Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 and Mills, Kenneth Ian 2007. FUS expression alters the differentiation response to all-trans retinoic acid in NB4 and NB4R2 cells. British Journal of Haematology 139 (1) , pp. 94-97. 10.1111/j.1365-2141.2007.06756.x

Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976, Hills, Robert Kerrin ORCID: https://orcid.org/0000-0003-0166-0062, White, Paul Charles ORCID: https://orcid.org/0000-0002-6562-4696, Rosie, B., Mills, Kenneth Ian, Burnett, Alan Kenneth and Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 2007. CD200 as a prognostic factor in acute myeloid leukaemia. Leukemia 21 (3) , pp. 566-568. 10.1038/sj.leu.2404559

Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976, Hills, Robert Kerrin ORCID: https://orcid.org/0000-0003-0166-0062, White, Paul Charles ORCID: https://orcid.org/0000-0002-6562-4696, Rosie, B., Mills, Kenneth Ian, Burnett, Alan Kenneth and Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 2007. CD200 as a prognostic factor in acute myeloid leukaemia [Letter]. Leukemia 21 (3) , pp. 566-568. 10.1038/sj.leu.2404559

Pearn, Lorna, Fisher, Janet, Burnett, Alan Kenneth and Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 2007. The role of PKC and PDK1 in monocyte lineage specification by Ras. Blood 109 (10) , pp. 4461-9. 10.1182/blood-2006-09-047217

Omidvar, Nader, Pearn, Lorna, Burnett, Alan Kenneth and Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 2006. Ral is both necessary and sufficient for the inhibition of myeloid differentiation mediated by Ras. Molecular and cellular biology 26 (10) , pp. 3966-75. 10.1128/MCB.26.10.3966-3975.2006
file

Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976, Pearn, Lorna, Mills, Kenneth Ian, Burnett, Alan Kenneth and Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 2006. The sensitivity of human cells expressing RUNX1-RUNX1T1 to chemotherapeutic agents. Leukemia 20 (10) , pp. 1883-5. 10.1038/sj.leu.2404364

Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976, Tonks, Amanda Jayne ORCID: https://orcid.org/0000-0002-6073-4976, Pearn, Lorna, Mohamad, Zulkhairi, Burnett, Alan Kenneth and Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 2005. Optimized retroviral transduction protocol which preserves the primitive subpopulation of human hematopoietic cells. Biotechnology Progress 21 (3) , pp. 953-958. 10.1021/bp0500314

Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976, Tonks, Amanda Jayne, Pearn, Lorna, Pearce, Laurence, Hoy, Terence George, Couzens, Stephen, Fisher, Janet, Burnett, Alan Kenneth and Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 2004. Expression of AML1-ETO in human myelomonocytic cells selectively inhibits granulocytic differentiation and promotes their self-renewal. Leukemia 18 (7) , pp. 1238-1245. 10.1038/sj.leu.2403396

Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976, Tonks, Amanda Jayne, Pearn, Lorna, Pearce, L., Hoy, T., Couzens, Stephen, Fisher, J., Burnett, Alan Kenneth and Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 2004. Expression of AML1-ETO in human myelomonocytic cells selectively inhibits granulocytic differentiation and promotes their self-renewal. Leukemia 18 (7) , pp. 1238-1245. 10.1038/sj.leu.2403396

Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976, Pearn, Lorna, Tonks, Amanda Jayne, Pearce, Laurence, Hoy, Terence George, Phillips, Sarah, Fisher, Janet, Downing, James R., Burnett, Alan Kenneth and Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 2003. The AML-1 fusion gene promotes extensive self-renewal of human primary erythroid cells. Blood 101 (2) , pp. 624-632. 10.1182/blood-2002-06-1732

Tonks, Alex ORCID: https://orcid.org/0000-0002-6073-4976, Pearn, Lorna, Tonks, Amanda Jayne, Pearce, Laurence, Hoy, Terence George, Phillips, Sarah, Fisher, Janet, Downing, James R., Burnett, Alan Kenneth and Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 2003. The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells. Blood 101 (2) , pp. 624-632. 10.1182/blood-2002-06-1732

Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724, Pearn, Lorna, Omidvar, Nader, Sweeney, Marion Carol ORCID: https://orcid.org/0000-0003-0713-0855, Fisher, Janet, Phillips, Sarah, Hoy, Terence George and Burnett, Alan Kenneth 2002. Protein kinase C mediates mutant N-Ras-induced developmental abnormalities in normal human erythroid cells. Blood 100 (12) , pp. 4185-92. 10.1182/blood-2002-05-1358

McGlynn, Angela P., Padua, Rose Ann, Burnett, Alan Kenneth and Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 2000. Alternative effects of RAS and RAF oncogenes on the proliferation and apoptosis of factor-dependent FDC-P1 cells. Leukemia Research 24 (1) , pp. 47-54. 10.1016/s0145-2126(99)00159-9

Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724, Pearn, Lorna and Burnett, Alan Kenneth 2000. Mutant RAS promotes amplification of primitive human erythroid cells. Blood 96 (11) , 92A-92A.

Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 and Burnett, Alan Kenneth 1999. Mutant RAS inhibits neutrophil but not macrophage differentiation and allows continued growth of neutrophil precursors. Experimental Hematology 27 (11) , pp. 1599-1608. 10.1016/S0301-472X(99)00100-9

Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724, Hoy, T. G., Robinson, L. and Burnett, Alan Kenneth 1998. Mutant N-RAS blocks granulocytic differentiation of human cd34+ cells. British Journal of Haematology 102 (1) , p. 289. 10.1111/j.1365-2141.1998.tb08997.x

Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724, Hoy, T. G. and Burnett, Alan Kenneth 1998. Mutant N-RAS blocks granulocytic differentiation of human CD34(+) cells [Abstract]. British Journal of Haematology 101 (S) , p. 22.

Gallagher, Andrea P., Burnett, Alan Kenneth, Bowen, David T. and Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 1998. Mutant RAS selectively promotes sensitivity of myeloid leukemia cells to apoptosis by a protein kinase C-dependent process. Cancer Research 58 (9) , pp. 2029-2035.

Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724, Gallagher, A. P., Bowen, D. T. and Burnett, Alan Kenneth 1997. Mutant RAS selectively promotes sensitivity of myeloid leukemia cells to apoptosis by a PKC-dependent process. Blood 90 (10) , p. 202.

Zaker, Farhad, Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724, Sabah, Ala Al and Burnett, Alan Kenneth 1997. Oncogenic RAS genes impair erythroid differentiation of erythroleukaemia cells. Leukemia Research 21 (7) , pp. 635-640. 10.1016/S0145-2126(97)00022-2

Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724, Hoy, Terence G., Baines, Paul, Padua, Rose Ann and Burnett, Alan Kenneth 1997. Mutant N-RAS induces erythroid lineage dysplasia in human CD34+ Cells. Journal of Experimental Medicine 185 (7) , pp. 1337-1348. 10.1084/jem.185.7.1337

Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724, Baines, Paul, Hoy, Terence G., Padua, Rose Ann and Burnett, Alan Kenneth 1996. Mutant N-RAS alters the developmental potential of human CD34(+) cells in a lineage-specific manner. British Journal of Haematology 93 (S2) , p. 597.

Evely, R. S., Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724, Gilkes, Amanda F., Goringe, A., Mirza, T. and Burnett, Alan Kenneth 1996. In-vivo modelling of myeloid malignancies using severe combined immunodeficient (SCID) mice [Abstract]. British Journal of Haematology 93 , p. 205.

Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724, Baines, Paul, Hoy, T. G. and Burnett, Alan Kenneth 1995. Mutant N-RAS induces erythroid lineage dysplasia in human CD34(+) progenitor cells. Blood 86 (10) , p. 1665.

Gallagher, A., Padua, R. A., Alsabah, A., Burnett, Alan Kenneth and Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 1994. P21RAS expression in leukemogenesis and hematopoiesis. Blood 84 (10) , A605-A605.

Morris, Alan G., Darley, Richard Lawrence ORCID: https://orcid.org/0000-0003-0879-0724 and Bateman, Wendy J. 1992. The loss of class II MHC antigen expression by ras-transformed murine fibroblasts passaged as tumours correlates with increased tumorigenicity but is not mediated by T cells. Cancer Immunology, Immunotherapy 35 (1) , pp. 46-52. 10.1007/BF01741054

This list was generated on Sat Apr 20 05:00:43 2024 BST.