Adenoviral vector targeting

Swift, Emma A. and Parker, Alan L. ORCID: https://orcid.org/0000-0002-9302-1761 2025. Adenoviral vector targeting. Curiel, David T. and Parker, Alan L., eds. Adenoviral Vectors for Gene Therapy, Elsevier, pp. 365-401. (10.1016/B978-0-323-89821-8.00017-6)

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Abstract

Adenoviruses are appealing candidates from which to construct vectors for gene and oncolytic virotherapy applications, in addition to serving as the backbones for novel vaccines. Nevertheless, relying on the tropisms of naturally-occurring serotypes to achieve therapeutic gene delivery is plagued by two perennial issues. Firstly, the collection of cells naturally infected by adenoviruses, while classically broad, is insufficient to encompass the diverse subsets affected by disorders that are alluring prospective candidates for virotherapy treatment. Conversely, their dependence on promiscuously-expressed cell entry receptors means encoded payloads may be delivered to multiple extraneous populations, culminating in the occurrence of dose-limiting toxicities. Circumventing these issues has necessitated the development of methods to manipulate vector capsids in order to alter the constellation of receptors these engage for infection. In this way, vector tropisms can be exquisitely fine-tuned to target their activities toward highly select cell populations, thereby mirroring the ultimate goals of adenovirotherapy.

Item Type:	Book Section
Date Type:	Published Online
Status:	Published
Schools:	Schools > Medicine
Publisher:	Elsevier
ISBN:	9780323898218
Funders:	Cancer Research UK
Date of Acceptance:	20 February 2025
Last Modified:	13 May 2025 09:42
URI:	https://orca.cardiff.ac.uk/id/eprint/177682

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