Technical recommendations for analyzing oxylipins by liquid chromatography–mass spectrometry

Schebb, Nils Helge, Kampschulte, Nadja, Hagn, Gerhard, Plitzko, Kathrin, Meckelmann, Sven W., Ghosh, Soumita, Joshi, Robin, Kuligowski, Julia, Vuckovic, Dajana, Botana, Marina T., Sánchez-Illana, Ángel, Zandkarimi, Fereshteh, Das, Aditi, Yang, Jun, Schmidt, Louis, Checa, Antonio, Roche, Helen M., Armando, Aaron M., Edin, Matthew L., Lih, Fred B., Aristizabal-Henao, Juan J., Miyamoto, Sayuri, Giuffrida, Francesca, Moussaieff, Arieh, Domingues, Rosário, Rothe, Michael, Hinz, Christine, Das, Ujjalkumar Subhash, Rund, Katharina M., Taha, Ameer Y., Hofstetter, Robert K., Werner, Markus, Werz, Oliver, Kahnt, Astrid S., Bertrand-Michel, Justine, Le Faouder, Pauline, Gurke, Robert, Thomas, Dominique, Torta, Federico, Milic, Ivana, Dias, Irundika H. K., Spickett, Corinne M., Biagini, Denise, Lomonaco, Tommaso, Idborg, Helena, Liu, Jun-Yan, Fedorova, Maria, Ford, David A., Barden, Anne, Mori, Trevor A., Kennedy, Paul D., Maxey, Kirk, Ivanisevic, Julijana, Gallart-Ayala, Hector, Gladine, Cécile, Wenk, Markus, Galano, Jean-Marie, Durand, Thierry, Stark, Ken D., Barbas, Coral, Garscha, Ulrike, Gelhaus, Stacy L., Ceglarek, Uta, Flamand, Nicolas, Griffin, Julian L., Ahrends, Robert, Arita, Makoto, Zeldin, Darryl C., Schopfer, Francisco J., Quehenberger, Oswald, Julian, Randall, Nicolaou, Anna, Blair, Ian A., Murphy, Michael P., Hammock, Bruce D., Freeman, Bruce, Liebisch, Gerhard, Serhan, Charles N., Köfeler, Harald C., Jakobsson, Per-Johan, Steinhilber, Dieter, Gelb, Michael H., Holčapek, Michal, Andrew, Ruth, Giera, Martin, FitzGerald, Garret A., Murphy, Robert C., Newman, John W., Dennis, Edward A., Ekroos, Kim, Milne, Ginger L., Gijón, Miguel A., Vesper, Hubert W., Wheelock, Craig E. and O’Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460 2025. Technical recommendations for analyzing oxylipins by liquid chromatography–mass spectrometry. Science Signaling 18 (887) , eadw1245. 10.1126/scisignal.adw1245

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Abstract

Several oxylipins are potent lipid mediators that regulate diverse aspects of health and disease and whose quantitative analysis by liquid chromatography–mass spectrometry (LC-MS) presents substantial technical challenges. As members of the lipidomics community, we developed technical recommendations to ensure best practices when quantifying oxylipins by LC-MS.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Additional Information:	License information from Publisher: LICENSE 1: URL: https://www.science.org/content/page/science-licenses-journal-article-reuse, Start Date: 2026-05-20
Publisher:	American Association for the Advancement of Science
ISSN:	1945-0877
Date of Acceptance:	24 April 2025
Last Modified:	09 Jun 2025 14:31
URI:	https://orca.cardiff.ac.uk/id/eprint/178928

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