Toll-like receptors in B cells and obesity

Wang, Pai, Hou, Can, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2025. Toll-like receptors in B cells and obesity. Trends in Molecular Medicine 10.1016/j.molmed.2025.05.005

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Abstract

Toll-like receptors (TLRs) play a pivotal role in both innate and adaptive immunity, primarily by detecting pathogen-associated molecular patterns (PAMPs) and orchestrating immune responses. Although TLR-driven activation of dendritic cells (DCs) and subsequent T cell differentiation are well characterized, the function of TLRs in B cells remains underexplored. In the context of obesity, excessive adipose tissue accumulation triggers chronic inflammation driven in part by activation of TLR signaling. This review explores the expression, function, and signaling mechanisms of TLRs in B cells, and emphasizes their role in modulating immune responses associated with obesity. Furthermore, we discuss how TLR-mediated inflammatory activity in B cells may contribute to metabolic dysregulation, and offer insights into the crosstalk between immune function and metabolic disease in obesity. [Abstract copyright: Copyright © 2025. Published by Elsevier Ltd.]

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Schools > Medicine
Publisher:	Cell Press
ISSN:	1471-4914
Date of Acceptance:	16 May 2025
Last Modified:	08 Jul 2025 09:15
URI:	https://orca.cardiff.ac.uk/id/eprint/179623

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