Uncovering the impact of the cardiovascular system on cerebrovascular health using MRI

Driver, Ian ORCID: https://orcid.org/0000-0001-6815-0134 and Murphy, Kevin ORCID: https://orcid.org/0000-0002-6516-313X 2025. Uncovering the impact of the cardiovascular system on cerebrovascular health using MRI. Experimental Physiology

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Abstract

Human cerebrovasculature is finely tuned to enable local changes in blood flow to meet the brain’s demands, whilst protecting the brain from systemic changes in blood pressure, both acutely during a heartbeat and chronically over time. This review summarises cerebrovascular structure and function, their role in disease and neurodegeneration and the part MRI measurements can play in probing them. MRI methods to measure various aspects of cerebrovascular physiology are described and placed in context of applications studying cerebrovascular health. The role of the cardiovascular system linking the cardiac pulse wave to cerebrovascular disease and gaps in mechanistic knowledge are highlighted.

Item Type:	Article
Status:	In Press
Schools:	Schools > Physics and Astronomy Research Institutes & Centres > Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	Wiley
ISSN:	0958-0670
Date of First Compliant Deposit:	19 August 2025
Date of Acceptance:	13 August 2025
Last Modified:	20 Aug 2025 09:15
URI:	https://orca.cardiff.ac.uk/id/eprint/180561

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