Beyond genes - a clinician’s guide to epigenetics

Popov, Petar and Jurkowska, Renata Z. ORCID: https://orcid.org/0000-0002-4507-2222 2025. Beyond genes - a clinician’s guide to epigenetics. Breathe Item availability restricted.

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Abstract

Epigenetic mechanisms control how and when our genes are switched on or off. They get altered by chronic environmental exposures, like cigarette smoke or air pollution, contributing to disease development. Excitingly, they can also be manipulated with the potential to target disease. Thus, epigenetic signalling provides a novel angle for understanding how chronic lung diseases develop and identifying novel biomarkers and therapeutic targets for respiratory diseases. This educational review is meant as a guide for clinicians and other lung researchers interested in epigenetic regulation. We introduce the main epigenetic modifications and the general cellular machinery that introduces and removes them. We provide selected examples of epigenetic dysregulation in response to environmental exposures and in chronic lung diseases. Finally, we discuss the promise of epigenetic biomarkers and therapies for clinical practice, including new precision medicine epigenetic editing approaches.

Item Type:	Article
Status:	In Press
Schools:	Schools > Biosciences
Publisher:	European Respiratory Society
ISSN:	1810-6838
Date of First Compliant Deposit:	3 September 2025
Date of Acceptance:	19 August 2025
Last Modified:	04 Sep 2025 10:45
URI:	https://orca.cardiff.ac.uk/id/eprint/180866

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