Recent updates in mammalian oxylipin biochemistry

O’Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460 2025. Recent updates in mammalian oxylipin biochemistry. Journal of Biological Chemistry 301 (10) , 110629. 10.1016/j.jbc.2025.110629

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Abstract

Oxylipins represent large families of bioactive lipids generated through the oxygenation of fatty acids. Although originally discovered almost 100 years ago, significant interest in these lipids continues today with many important discoveries on their structures and functions still being made, particularly in regards to mammalian biology. This review will highlight some aspects of the current status of the field, focusing on recent findings that continue to challenge our views about how oxylipins are made and act in human health and disease. Areas to be covered include: an update on the ever-expanding roles of PGE2 in cancer, octadecanoid structures and nomenclature, complex forms of oxylipins, and challenges and considerations for oxylipin analysis including potential clinical utility.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Publisher:	Elsevier
ISSN:	0021-9258
Date of First Compliant Deposit:	29 September 2025
Date of Acceptance:	20 August 2025
Last Modified:	29 Sep 2025 11:31
URI:	https://orca.cardiff.ac.uk/id/eprint/180973

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