Decoding brain structure-function dynamics in health and in psychosis via an autoencoder

Cai, Qing, Thomas, Hannah, Hyde, Vanessa, Luque Laguna, Pedro, McNabb, Carolyn B. ORCID: https://orcid.org/0000-0002-6434-5177, Singh, Krish D. ORCID: https://orcid.org/0000-0002-3094-2475, Jones, Derek K. ORCID: https://orcid.org/0000-0003-4409-8049 and Messaritaki, Eirini ORCID: https://orcid.org/0000-0002-9917-4160 2025. Decoding brain structure-function dynamics in health and in psychosis via an autoencoder. Scientific Reports 15 , 40052. 10.1038/s41598-025-24232-z

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Abstract

Understanding the intricate relationship between brain structure and function is a cornerstone challenge in neuroscience, critical for deciphering the mechanisms that underlie healthy and pathological brain function. In this work, we present a comprehensive framework for mapping structural connectivity measured via diffusion-MRI to resting-state functional connectivity measured via magnetoencephalography, utilizing a deep-learning model based on a Graph Multi-Head Attention AutoEncoder. We compare the results to those from an analytical model that utilizes shortest-path-length and search-information communication mechanisms. The deep-learning model outperformed the analytical model in predicting functional connectivity in healthy participants at the individual level, achieving mean correlation coefficients higher than 0.8 in the alpha and beta frequency bands, in comparison to 0.45 for the analytical model. Our results imply that human brain structural connectivity and electrophysiological functional connectivity are tightly coupled. The two models suggested distinct structure-function coupling in people with psychosis compared to healthy participants ( for the deep-learning model, in the delta band for the analytical model). Importantly, the alterations in the structure-function relationship were much more pronounced than any structure-specific or function-specific alterations observed in the psychosis participants. The findings demonstrate that analytical algorithms effectively model communication between brain areas in psychosis patients within the delta and theta bands, whereas more sophisticated models are necessary to capture the dynamics in the alpha and beta band.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Schools > Psychology Research Institutes & Centres > Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	Nature Publishing Group
ISSN:	2045-2322
Date of First Compliant Deposit:	14 October 2025
Date of Acceptance:	13 October 2025
Last Modified:	20 Nov 2025 10:36
URI:	https://orca.cardiff.ac.uk/id/eprint/181662

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