Kopp, Richard O., Rigo, Massimo, Groth, Lucie J., Coles, Nathan T.  ORCID: https://orcid.org/0000-0001-6190-9080, Neale, Samuel E., Frank, Samantha, Ernst, Moritz J., Weber, Manuela and Müller, Christian
2025.
Dynamic activation of alcohols by an electrophilic phosphinine.
Chemical Communications
10.1039/d5cc05302a
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License URL: https://creativecommons.org/licenses/by/3.0/
License Start date: 17 October 2025
Official URL: https://doi.org/10.1039/d5cc05302a
Abstract
A bis(trifluoromethyl)-substituted phosphinine undergoes reversible oxidative addition of primary and secondary alcohols at the low-coordinate phosphorus(iii) atom. This unprecedented reactivity contrasts the general inertness of uncoordinated phosphinines toward protic substrates and provides a rare example of reversible alcohol activation mediated by a main-group element compound. DFT calculations suggest that a hydrogen-bonded methanol network enables the transformation, offering a new concept for dynamic E–H bond activation by electrophilic, aromatic phosphorus heterocycles.
| Item Type: | Article |
|---|---|
| Date Type: | Published Online |
| Status: | In Press |
| Schools: | Schools > Chemistry |
| Additional Information: | License information from Publisher: LICENSE 1: URL: https://creativecommons.org/licenses/by/3.0/, Start Date: 2025-10-17 |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1359-7345 |
| Date of First Compliant Deposit: | 5 November 2025 |
| Date of Acceptance: | 15 October 2025 |
| Last Modified: | 06 Nov 2025 02:30 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/182131 |
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